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1.
Korean Journal of Pediatric Hematology-Oncology ; : 247-252, 2004.
Artículo en Coreano | WPRIM | ID: wpr-74194

RESUMEN

Chloroma, a tumor consisted of primitive myeloid cells and located in extramedullary tissues, usually develops during or preceding the course of systemic leukemia, particularly acute myelogenous leukemia (FAB M2) with translocation between chromosomes 8 and 21. Leukemic retinopathy which observed rarely in children than adults, generally related to thrombocytopenia and anemia in leukemic patients. Bronchiolitis obliterans organizing pneumonia (BOOP) is unusual clinicopathologic syndrome in association with a variety of causes or conditions, and histologically defined by the presentation of granulation tissue plugs consisting of fibroblasts and collagen within the lumen of the distal air space. We experienced a 12-year old girl who presented with weakness and ocular pain. She was diagnosed with acute myeloid leukemia with chloroma and retinopathy, and treated with chemotherapy (daunomycin, ara-C, thioguanine, etoposide. mitoxantrone, cyclosporin). Five weeks after the chemotherapy, she developed coughing and persistent fever, and diagnosed with BOOP, which resolved completely after prednisolone therapy.


Asunto(s)
Adulto , Niño , Femenino , Humanos , Anemia , Bronquiolitis Obliterante , Bronquiolitis , Colágeno , Tos , Neumonía en Organización Criptogénica , Citarabina , Quimioterapia , Etopósido , Fiebre , Fibroblastos , Tejido de Granulación , Leucemia , Leucemia Mieloide Aguda , Mitoxantrona , Células Mieloides , Prednisolona , Sarcoma Mieloide , Tioguanina , Trombocitopenia
2.
Journal of the Korean Pediatric Society ; : 622-628, 2002.
Artículo en Coreano | WPRIM | ID: wpr-223348

RESUMEN

PURPOSE: The purpose of this study is to ascertain the clinical manifestations and associated cardiac anomalies of dextrocardia. METHODS: Twenty-four pediatric patients, who were admitted to, or visited, Dongsan Medical Center Keimyung University and were diagnosed with dextrocardia between January 1996 and July 2001, were enrolled in this study. All patients received echocardiogram and abdominal ultrasonogram to identify structural cardiac anomalies and visceral position. RESULTS:Among 24 patients, 7 cases were situs solitus(29.2%), 10 cases(41.6%) were situs inversus and 7 cases(29.2%) were situs ambiguous. Most were diagnosed within a week of life(87.5%). They were most commonly cyanotic(45.8%), but eleven cases(45.8%) had no specific symptoms or signs. Nineteen cases(79.2%) had accompanied cardiac anomalies, and pulmonary stenosis or atresia were the most common among them. All the cases of situs solitus and ambiguous had associated cardiac anomalies, but half of the situs inversus had that. Eleven cases were dead by cardiac or extracardiac anomalies during follow up and the mortality rate was higher in situs solitus or ambiguous group than situs inversus group. CONCLUSION: Dextrocardia accompanies different cardiac and extracardiac anomalies. It's very important to diagnose dextrocardia and associated cardiac or extracardiac anomalies in the early stages of life to improve prognosis.


Asunto(s)
Humanos , Dextrocardia , Estudios de Seguimiento , Mortalidad , Pronóstico , Estenosis de la Válvula Pulmonar , Situs Inversus , Ultrasonografía
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