Secondary acute myeloid leukemia after platinum based chemotherapy for ovarian cancer / 대한산부인과학회지

Among chemotherapeutic regimens used for advanced ovarian cancer, platinum-based combination chemotherapy remains a mainstay of the treatment of advanced ovarian cancer, providing significant response rates and survival benefits. However, with widespread use of long-term chemotherapy in treating ovarian cancer, emergence of secondary leukemia has become medical concern as one of the most unfavorable late complications. Depending upon the type, duration, and dosage of previous chemotherapy, the risk of developing acute myeloid leukemia has been estimated to be between 2% and 10%. Moreover, the frequency of this complication might increase as the survival in patients with ovarian cancer undergoing chemotherapy continues to increase with developing therapeutic options. Recently, we experienced a case of secondary acute myeloid leukemia developing 3.5 years after platinum-based chemotherapy. In this report, clinical course of the patient and contributing factors for the secondary leukemia were presented.

A Case Of Intraperitoneal Hemorrhage Of Intraligamentary Pregnancy / 대한산부인과학회잡지

A case of intraperitoneal hemorrhage of intraligamentary pregnancy is one of the most unusual accidents in obstetrics and carries a high degree of maternal and fetal morbity and mortality. The diagnosis of intraligamentary pregnancy is rarely ever made prior to laparotomy. We report a case of it with a brief review of literatures concerned.

A Case Of Squamous Cell Carcinoma Arising In Mature Cystic Teratoma Of Left Ovary / 대한산부인과학회잡지

Mature cystic teratoma of the ovary is the most common ovarian germ cell neoplasm representing 10-20% of all ovarian tumors. Malignant transformation rarely takes place, which is approximately 1-2% of all cases. The most common malignancy arising in mature cystic teratoma is squamous cell carcinoma. The prognosis of malignant transformation developing in mature cystic teratoma is poor and the management is not established due to the rarity of malignant degeneration. A case of stage Ia squamous cell carcinoma which developed in mature cystic teratoma of left ovary in a 43-year-old female is presented. The ovarian tumor was woman's fist-sized with intact capsule. Left oophorocystectomy was done. Above case with a brief review of literature is given.