Generalized lymphadenopathy: a case report of rosai-dorfman disease

Sinus histiocytosis with massive lymphadenopathy [SHML], Rosai-Dorfman Disease, is a rare histiocytic syndrome first described by Rosai and Dorfman, seen predominantly in childhood and early adulthood. Even though it is considered a benign disease, fatalities may occur due to cellular infiltrates of SHML. We report a 16-year-old boy with signs of polydypsia, polyuria, weight loss and generalized lymphadenopathy. He had been receiving corticosteroid following the diagnosis of histiocytosis X. Due to hyperglycemia, the patient was admitted with the primary diagnosis of diabetic ketoacidosis and medications were initiated. All paraclinical and immunologic examinations were negative. Axillary lymph node biopsy revealed the diagnosis of Rosai-Dorfman disease

Mycobacterium thermoresistibile infection in a child

Mycobacterium thermoresistibile was first reported in 1981 as a human pathogen. Several studies have reported pulmonary infection and cutaneous lesions due to this type of mycobacterium. A five-year-old boy with cough, fever, and abdominal pain was referred to Masih Daneshvari Hospital. He had been treated with diagnosis of histiocytosis x. Gastric lavage was performed and examined by polymerase chain reaction [PCR] and Mycobacterium thermoresistibile was found. It seems that this case is the first report of an atypical tuberculosis caused by Mycobacterium thermoresistibile in a child