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Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (5 Supp.): 1833-1837
en Inglés | IMEMR | ID: emr-184119

RESUMEN

Conocarpus lancifolius [Combretaceae], " ÏãÓ ÓäÇäí " in Arabic, is distributed in Riyadh, Saudi Arabia. It is a heat-tolerant Saudi medicinal plant, demonstrates prominent antidiabetic potential and the fruit extract fruits showed cytotoxicity against MRC-5 cancer cell line, as well as prominent antiprotozoal and antibacterial activities. The objective of this study is to isolate the compounds and evaluate the anti-inflammatory, cytotoxic, PPAR agonistic and antioxidant activities of extracts and pure constituents from C. lancifolius. A new trimethoxyellagic acid derivative 1 and two compounds, kaempferol 3-O-rutinoside 2 and beta-sitosterol glucoside 3 were isolated from the fruits of Conocarpus lancifolius, a heat-tolerant plant. Compound 2 showed strong dual activation for PPAR alpha and PPAR gamma with 2.6 fold increment in PPAR alpha activity, while 2.2 fold increment in PPAR gamma at 25 micro g/mL. This is first report on isolation and screening of different biological activities of extract and pure constituents from fruits of C. lancifolius

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