RESUMEN
Hairy cell leukemia (HCL) is a rare chronic B-cell leukemia accounting for 2% of all the leukemias and occurs more frequently in the elderly males. The etiology is unknown but possible relationships to radiation exposure, exposure to benzene, to farm animals and to commercial herbicides and pesticides have been identified. Familial predisposition among first degree relatives has been noted. It is characterized by distinctive cytoplasmic “hair like” projections on the cell surface of lymphoid cells, pancytopenia and splenomegaly. We report a rare case of 29 year old female, farm labourer presenting with fever, fatigue and weakness for 1 month. On examination the patient had hepatomegaly, massive splenomegaly and inguinal lymphadenopathy. After peripheral smear examination diagnosis of HCL was made which was confirmed by bone marrow aspiration examination, bone marrow biopsy and immunohistochemistry (IHC).
RESUMEN
Schwannian stroma poor calcified bilateral neuroblastoma of adrenal gland in 14 year old male patient is an exceptionally uncommon, malignant tumor that is derived from the primitive neural crest cells of the adrenal medulla. Neuroblastoma is the fourth most common malignancy of childhood up to five years of age, and very occasionally seen after that. It rarely occurs in the adrenal gland after ten years of age and bilaterally. The diagnosis was established based on clinical, radiological, histopathological and immunohistochemical features. At present, the patient is on chemotherapy and radiotherapy but the recent MRI is showing bilateral pubic bone and femur metastasis. Conclusion: Schwannian stroma poor calcified bilateral neuroblastoma of adrenal gland is a rare tumor at the age of 14 years which needs precise histopathological assessment and confirmation by Immunohistochemistry.