Effect of citrate phosphate dextrose solution on reperfusion injury in coronary artery bypass surgical patients undergoing cardiopulmonary bypass

Reperfusion injury is one of the most common phenomena associated with coronary artery bypass graft [CABG] .The mechanism of ischemia and reperfusion injury is not known precisely, but may be free radicals and other activated oxygen metabolites have an important role in tissue damage following reperfusion injury. This study was to evaluation of citrate solution effects on oxidative stress and cardiac function and Cardiac enzymes in patient's candidate to CABG. In Double blind clinical trial study in Tabriz University of medical science, 50 patients candidate to CABG randomly divided in two groups and matched together according to sex, age and NYHA class. In intervention group after surgery and before the opening of the aortic clamping solution warm blood containing citrate phosphate dextrose [CPD; 3cc/100cc], value [100cc/min/m2BSA] for three minutes was administered. In control group, only pure blood administered. Oxidative stress markers measured in five stages and cardiac enzymes measured in three stages of surgery. Mean age 62.3 +/- 9.1 years including 30[60%] men and 20[40%] women. Ejection fractions between two groups were not significant before and after treatment. Administration of CPD was not significant effects on cardiac enzyme. Measurement of oxidative stress in different time were not different in Malonil Di Aldehid, superoxide dismutase and GPx but total antioxidant status were improved after intervention in compared with control group [p<0.001]. Results showed that CPD were positive effects of increasing in total antioxidant status after CABG. but in reduction of other oxidative markers were unlabeled

History of fertility and coronary artery disease in Iranian women older than 50 years old

Coronary artery disease [CAD] is a leading cause of mortality and disability in Iranian population. In this study, the association between parity and the presence of CAD in women more than 50years old age has been investigated in case [100 female patients with documented angiography-defined CAD] and control [320 female subjects with normal echocardiogram] group. Logistic regression analysis revealed that number of pregnancies and hysterectomy with ovarectomy was independent risk factors associated with CAD in this study