RESUMEN
To see the various clinical presentations and biochemical profile in adult celiac disease patients of Hyderabad Sindh. A total 60 suspected cases of adult celiac disease, both males and females were screened out from liaquat University of Medical and Health Sciences hospital and private clinics at Sadar Hyderabad Sind by non probability purposive sampling during a period from July 2011 to December 2012.Age ranged between 18 to 55 Years. A detailed history and clinical examination was done. Patients already on gluten free diet, age < 12years, tuberculosis or cancer of intestine/colon and patients of diabetes and thyroid disorder were excluded, while patients having positive ant tTG [value > 15 iu/ml detected by ELISA] were included. The biochemical profile including serum albumin, calcium, ferritin, SGPT, Alkaline phosphatase and Haemoglobin were estimated in central Diagnostic laboratory LUMHS by taking 10 cc centrifuged blood sample. The data was plotted on SPSS 16, mean and percentages were calculated. All patients were divided in to three groups according to age. The most common group was 18-30 years; [mean, 23.5 +/- 5.6] comprised 56.6%. The commonest clinical presentation was diarrhoea in 50%, menstrual irregularity in 21%, walking problems 21%, undue fatigue in 15% and edema in 15%. P values calculated in quantitative variable of males and females. The p value was significant in between serum calcium [p 0.004], haemoglobin [p 0,004], serum ferritin [< 0.005] and alkaline phosphatise [< 0.005]. This study showed that Adult celiac disease was present with entirely different clinical and biochemical profile in patients in this region
RESUMEN
"Both in importance and in time, health precedes disease, so we ought to consider first how health may be preserved and then how one may best cure disease" [Galen A.D. 200]. In Unani system of medicine there is a concept of six essentials of life [Asbab-e-Sitta Zarooriah] i.e. Air, Water, Solid and Liquid diet, Activity and Repose, Sleep and Wakefulness, Retention and Evacuation. In order to maintain our health it is necessary to keep these factors at optimum level and it is also necessary in the prevention of carcinoma. A large number of carcinomas are caused or promoted by change in life style factors, controllable by society or individual or both. Tobacco use, alcohol addiction and certain dietary components arc the most well established risk factors. Carcinoma prevention can be achieved by avoiding preventable etiological factors i.e. dietary factors, occupational factors and environmental risk factors. Dietary recommendation, an education about carcinoma prevention and role of physician by focusing on such causative factors, may be effective tools in the fight against carcinoma