Clinical assessment of non-sedating histamine H1 antagonists in treating patients with chronic idiopathic urticaria

Chronic idiopathic urticaria is a major problem in every day practice. H1 antagonist anti-histamines are the drugs of choice for its symptomatic treatment. The ordinary sedating anti-histamines are replaced by the non-sedating group. Terfenadine Astemizole and Loratadine are members of this group. The three drugs were assessed in an open label study for 4 weeks in treating 80 patients with chronic urticaria who completed the study. It came to the conclusion that the 3 drugs have significant effects in controlling the pruritus in different degrees. Loratadine was proved to be superior than Astemizole in efficacy but the difference was not statistically significant, P = 0.46. Both Loratadine and Astemizole were superior than Terfenadine in efficacy with a significant statistical difference, P < 09.05 for Astemizole/Terfenadine. No side reactions were reported in patients taking Loratadine and Astemizole, but only one patient [4%] in the Terfenadine group had dry mouth and one patient [4%] had eye irritation

Sexually transmitted urethritis in male patients: a clinical bacteriological study

Sexually transmitted urethritis in males is caused by many organisms, 59 male patients were examined to elucidate the etiological agents. Different types of organisms were detected, and serological scar of chlamydial infection was detected in the cases examined. Neisseria gonorrhea was detected in 12 cases [20.34 percent], Non gonococcal [other bacteria] were detected in 17 cases [28.81 percent], chlamydia was detected in 3 cases [5.08 percent], bacterial flora was detected in 22 cases [37.29 percent] and no organism was recorded in 5 cases [8.48 percent]. All the cases showed >5 PMN/HPF urine samples. High serum antichlamydial antibody titre was detected in 66.67 percent of Gonococcal cases, 5.88 percent of non gonococcal cases, 100 percent in chlamydial cases, and in 48.15 percent of cases with bacterial flora. This study supports the previous studies for treating cases of GU and NGU for chlamydia as well because of co-infection