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Journal of Southern Medical University ; (12): 170-179, 2016.
Artículo en Chino | WPRIM | ID: wpr-232489

RESUMEN

<p><b>OBJECTIVE</b>To construct a breast cancer gene-drug network model for extracting and predicting the correlations between breast cancer-related genes and drugs.</p><p><b>METHODS</b>We developed an algorithm based on the ABC principle and the association rules to obtain the correlations between the biological entities. For breast cancer, we constructed 3 different correlations (gene-gene, drug-drug and gene-drug) and used the R language to implement the associated network model. The reliability of the algorithm was verified by ROC curve.</p><p><b>RESULTS</b>We identified 185 breast cancer-associated genes and 98 associations between them, 97 drugs and 170 associations between them. The breast cancer genes-drugs network contained 127 genes and 77 drugs with 384 associations between them.</p><p><b>CONCLUSIONS</b>We identified a large number of different correlations between the breast cancer-related genes and drugs and close correlations between some biological entity pairs that have not yet been reported, which may provide a new strategy for experimental design for testing personalized breast cancer treatment.</p>


Asunto(s)
Femenino , Humanos , Algoritmos , Antineoplásicos , Farmacología , Neoplasias de la Mama , Genética , Redes Reguladoras de Genes , Genes Relacionados con las Neoplasias , Curva ROC , Reproducibilidad de los Resultados
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