RESUMEN
Background: Endomyocardial fibrosis has varied presentatation and difficult to diagnose. Aim to elucidate the role of Cardiac Magnetic Resonance (CMR) imaging in the evaluation of Endomyocardial Fibrosis (EMF) and to devise diagnostic criteria for the disease.Methods: Retrospective analysis of cases of restrictive cardiomyopathy referred for Magnetic resonance imaging over a period of 5 years. All patients underwent 1.5 T CMR imaging (Magnetom Avanto, Siemens, Germany) with standard cardiomyopathy protocol. Criteria for diagnosis of RCM included normal sized ventricles, normal/reduced systolic function, uni-/bi-atrial enlargement, normal pericardium and absent septal bounce. Cases diagnosed as EMF on CMR were included in this study. Statistical analysis performed using SPSS software.Results: EMF was diagnosed in 20 patients (31%) [12 males; age 39±18 years]. Ten patients had Right Centricular (RV) EMF, 3 had Left Ventricular (LV) EMF, while 7 had bi-ventricular EMF. Oedema indicating ongoing inflammation was seen in 4 (20%) cases. Apical thrombus was seen in 8(40%) cases and was present in 35% cases of RV and 20% cases of LV involvement. Subendocardial delayed enhancement was always present in the involved ventricle. The RV apex was obliterated in 100% of patients with RV EMF, while LV apex was similarly obliterated in 66% cases with LV disease. Mild-moderate pericardial effusion was observed in 8 patients. On the basis of CMR findings, the disease was classified as early necrotic phase in 1, thrombotic necrotic in 4 and late fibrotic phase in 13 and of different stages in ventricles in 2 cases.Conclusions: EMF was the commonest cause of RCM in this series. Major diagnostic criteria of EMF on CMR include subendocardial delayed enhancement and apical obliteration. Oedema and thrombus are variable findings, depending on disease severity.
RESUMEN
Background: The load of coronary artery disease is on therise worldwide, developing countries, Like India, are acceptinglifestyle alterations that predispose to cardiovascular disorders.The present study was conducted with the aim to determinethe role of carotid intima media thickness in predictingcardiovascular events.Materials and Methods: The present prospective study wasperformed in the Department of Cardiology, Dr. Ram ManoharLohia Hospital & PGIMER, New Delhi, India. A detailed historyof all the subjects including medical history, biochemicalevaluation and ECG was performed amongst all the patients.The thickness of internal carotid artery and common carotidartery were measured bilaterally. A total of 3 readings wereobtained and mean was calculated. All the data thus obtainedwas arranged in a tabulated form and analyzed using SPSSsoftware.Results: A total of 200 subjects were enrolled in the study, themean age of the subjects was 44.87+/-3.89 years. There were120 males and 80 females in the study. The mean thickness ofright common carotid amongst cases was 0.12 ± .0085 andamongst control was 0.05 ± 0.0095. There was a significantdifference between the two as the p value was less than 0.05.Conclusion: Association between intimal thickness andcoronary artery disease is significant. Atherosclerosis is evenlydistributed amongst vasculature and primarily responsible forheart diseases.