1.
J Biosci
; 1985 Dec; 9 (3&4): 231-236
Artículo
en Inglés
| IMSEAR
| ID: sea-160498
RESUMEN
A DNA polymerase activity associated with the detergent insoluble cytoskeletal fraction has been identified in dividing and non-dividing rat hepatocytes and a hepatoma (the Zajdela Ascitic Hepatoma). About 35 % of the enzyme is found associated with the cytoskeletal fraction of non-dividing cells as compared to about 3–6 % of the enzyme in dividing cells even though the dividing cells contain larger amounts of the extranuclear enzyme. The properties of the enzyme are similar to those of DNA polymerase-α. It is suggested that the association of the enzyme with the cytoskeletal fraction has functional significance.