RESUMEN
An experiment was conducted to study the electrolytes alteration in experimentally induced mercuric chloride in wistar rat. For this rats were uniformly divided in four different dose group 0.0, 2.0, 4.0, and 8.0 mg/kg body weight ranging from asymptomatic to high dose for 28 consecutive days. In this experiment, blood was collected on 0, 14 and at the end of experiment. In mercuric chloride treated group dose dependent significant increase in plasma glucose, sodium, and chloride and creatinine level. Same parameters studied in urine showed significant increase in excretion of electrolytes and glucose in urine while urine creatinine was decrease. Mercuric chloride produced dose depended electrolytes alteration in wistar rat at given dose.
RESUMEN
The antimicrobial growth promoter includes varieties of chemotherapeutics agent to be used for improving feed conversion efficiency, body weight gain and overall health. Now a day due to increased pressure of augmenting productivity, the animal husbandry industry is favorably inclined to professional use of antimicrobial growth promoters. AGP are administered at very low dose and they modify the bacterial quality and quantity in animal body towards favorable outcome with respect to reduced incidence of some diseases and infections. Today, non inophore group of compounds are being used widely for the purpose. These compounds alter the cell membrane permeability and causes death of bacterial cells. Wide varieties of compounds are available with specific purpose. The most ideal characteristic of AGP desired is minimum tissue residue and no cross resistance with human pathogens. The total amount of AGP used is difficult to estimate. The present review discusses the detail aspect of AGP at length.
RESUMEN
Mercury is the highly toxic metal that exerts its adverse effect on health of human and animals through air, soil water and food. For the present study, the toxic effect was observed by oral administration of mercuric chloride daily for 4 weeks at doses ranging from of 0 to 8 mg/kg/day. Histopathology was also carried out of both for kidney and liver. Significantl increased in lipid peroxidation and decreased Superoxide dismutase enzymes were observed in treated groups as compared to control . The gross changes were characterized by swellingand paleness of kidney and liver. Microscopic examination has revealed liver revealed hemorrhage, leukocytic infiltration, hepatocyte hypertrophy, necrosis and increased vacuolization incidence and the severity increased with increase treatment dose. In addition kidney showed proteineous cast in the lumen of tubules, narrowing of lumen, infiltration and necrosis.