RESUMEN
An eight-year-old male child presenting with history of generalized convulsions, gradual loss of speech and generalized EEG (electroencephalography) abnormalities was diagnosed as Landau Kleffner Syndrome. He initially developed generalized convulsions which later changed to partial seizures during the course of illness. He was started on sodium valproate and continued with the drug (30 mg/kg/day) on which, he showed improvement in speech, behavior, hyperkinesis and frequency of convulsions during the follow-up.
Asunto(s)
Niño , Diagnóstico Diferencial , Electroencefalografía , Humanos , Síndrome de Landau-Kleffner/diagnóstico , Masculino , Ácido Valproico/uso terapéuticoRESUMEN
OBJECTIVE: Evaluation of immunogenicity and acceptability of PRP-T vaccine among the Indian children. DESIGN: Multicentric, open, parallel group, comparative study of Haemophilus influenzae type B vaccine, given as single (Group I) or associated (Group II) with DPT vaccine. SETTING: Five different vaccination clinics. SUBJECTS: 125 children between the age group of 18-24 months. PARAMETERS: Measurement of (i) pre and post vaccination antibody titres of Haemophilus influenze type B specific antibody; (ii) Adverse events; and (iii) Tolerance as graded by the physician. RESULTS: Prevaccination antibody levels were > 0.15 mcg/ml in 56.3% in Group I and 35.7% in Group II. Post-seroconversion was seen in 97% in Group II receiving single and all in Group II (P > 0.05). The vaccine was well tolerated. CONCLUSIONS: The probability of subclinical infection or cross immunity is high in India. ACTHIB vaccine has a good immunogenicity and tolerance and association with DPT does not modify the immunogenicity of ACTHIB vaccine.
Asunto(s)
Antígenos Bacterianos/sangre , Países en Desarrollo , Estudios de Evaluación como Asunto , Femenino , Infecciones por Haemophilus/inmunología , Vacunas contra Haemophilus/administración & dosificación , Haemophilus influenzae/inmunología , Humanos , India , Lactante , Masculino , VacunaciónRESUMEN
Acute respiratory infections (ARI) account for 20-24% of childhood deaths in India. The present study investigated the host related risk factors in the outcome of pneumonia in 127 hospitalised children between the ages of 2 months and 5 years. The case fatality rate in the study was 11.8%. Presence of malnutrition is a significantly important factor for both increased duration of pneumonia and fatal outcome. Other factors for increased pneumonia mortality include the presence of associated illness and the severity of the pneumonia.