RESUMEN
Many herbal medicines have been recommended for the treatment of diabetes. The antidiabetic effect of date pits powder and date pollen grains powder investigated in normal and Alloxan -induced diabetic rats. The rats were divided into 4 groups, first group as normal rats, 2 as diabetic rats without treatment, 3 fed on 25% of date pits powder and 4 fed on 2% of date pollen grains powder. The nutritional experiment was continued for 45 days. Blood samples of non-diabetic and diabetic rats were collected, after 3 days, 15 days and 45 days from administration of Alloxan where serum glucose change were estimated. Other biochemical assays were estimated after 3 days and 45 days only. The results show that the basal diet supplemented by date pits powder and date pollen grains powder induced a decrease in serum glucose, total cholesterol, triglycerides and total lipids and increase in urea and creatinine. The basal diet supplemented with date pits powder or date pollen grains powder showed decrease in weights of liver, kidney and pancreas. While, it showed increase in heart weight. The results from histopathology show no changes in kidney, heart, spleen and pancreas. But, the liver in experimental rats fed on 2% date pollen grains powder showed no change except activation of kupffer cells