RESUMEN
This study was done to investigate whether tin chloride [Sncl[2]] pretreatment ameliorates renal injury in rats with toxic or ischaemia acute renal failure [ARF]. It was carried out on 100 adult male albino rats weighing 180-220 gm. Rats were divided into 5 numerically equal groups [each contains 20 animals]. Control group [received physiological saline] group pretreated with physiological saline before single subcutaneous[S.C.] injection of potassium dichromate [K[2]Cr[2]O[7] in a dose of 25 mg/kg, group treated with Sncl[2][10 mg/100 g BW, subcutaneously] 12 hours before K[2]Cr[2]O[7] and group subjected to renal ischaemia. The group of renal ischaemia were subdivided into 2 groups: pretreatment with the same volume of physiological saline 24 hrs before ischaemia and pretreatment with Sncl[2] [10 mg/100g Bw, subcutaneously] 24 hrs before ischaemia,. After the desired period of treatment, animals were killed at different intervals of time. Blood was collected to investigate the renal functions [bloo urea nitrogen and serum creatinine], and kidneys wer examined histopathologically. The results revealed that, K2Cr2O7 and renal ischaemia markedly increased renal functions. Histological sections of ARF treated rats revealed an extensive tubular cell necrosis. Tin chloride pretreatment which specifically induced renal heme oxygenase activity in the rat ameliorated the toxic and ischaemia renal i njury as judged by the significant decrease in serum creatinine and blood urea concentrations and the lesser tubular cell injuries