Depression status of elderly patients with metabolic syndrome in three provinces of China / 中华流行病学杂志

Objective: To understand the depression status and its influencing factors in elderly patients with MS in China and to explore the correlation between various components of elderly MS and depression. Methods: This study is based on the "Prevention and Intervention of Key Diseases in Elderly" project. We used a multi-stage stratified cluster random sampling method to complete 16 199 elderly aged 60 years and above in 16 counties (districts) in Liaoning, Henan, and Guangdong Provinces in 2019, excluding 1 001 missing variables. Finally, 15 198 valid samples were included for analysis. The respondents' MS disease was obtained through questionnaires and physical examinations, and the respondents' depression status within the past half month was assessed using the PHQ-9 Depression Screening Scale. The correlation between elderly MS and its components and depression and its influencing factors were analyzed by logistic regression. Results: A total of 15 198 elderly aged 60 years and above were included in this study, with the prevalence of MS at 10.84% and the detection rate of depressive symptoms in MS patients at 25.49%. The detection rates of depressive symptoms in patients with 0, 1, 2, 3, and 4 MS abnormal group scores were 14.56%, 15.17%, 18.01%, 25.21%, and 26.65%, respectively. The number of abnormal components of MS was positively correlated with the detection rate of depressive symptoms, and the difference between groups was statistically significant (P<0.05). The risk of depression symptoms in patients with MS, overweight/obesity, hypertension, diabetes, and dyslipidemia was 1.73 times (OR=1.73, 95%CI:1.51-1.97), 1.13 times (OR=1.13, 95%CI:1.03-1.24), 1.25 times (OR=1.25, 95%CI:1.14-1.38), 1.41 times (OR=1.41, 95%CI:1.24-1.60), 1.81 times (OR=1.81,95%CI:1.61-2.04), respectively, more than those without the disease. Multivariate logistic regression analysis showed that the detection rate of depressive symptoms in patients with sleep disorders was higher than that with normal sleep (OR=4.89, 95%CI: 3.79-6.32). The detection rate of depressive symptoms in patients with cognitive dysfunction was 2.12 times higher than that in the average population (OR=2.12, 95%CI: 1.56-2.89). The detection rate of depressive symptoms in patients with impaired instrumental activities of daily living (IADL) was 2.31 times (OR=2.31, 95%CI: 1.64-3.26) higher than that in the average population. Tea drinking (OR=0.73, 95%CI: 0.54-0.98) and physical exercise (OR=0.67, 95%CI: 0.49-0.90) seemed to be protective factors for depression in elderly MS patients (P<0.05). Conclusions: Older patients with MS and its component abnormalities have a higher risk of depression than the average population. Sleep disorders, cognitive impairment, and IADL impairment are important influencing factors for depression in elderly MS patients, while tea drinking and physical exercise may help to reduce the risk of the disease.

Multiple vulvar dilated pores in a postmenopausal woman

Abstract: Winer's dilated pore is an infrequent appendageal tumor characterized by a giant comedone on the face, neck, and upper trunk in adults. We report a 57-year-old woman who developed multiple asymptomatic black papules on both labia majora. Histopathology showed grouped dilated follicles lined by keratinizing squamous epithelium in the superficial dermis. The superficial lining epithelium and interfollicular epidermis were atrophic, while the deep epithelium showed mild proliferation and melanin pigmentation with a few short projections extending into the surrounding dermis. We diagnosed multiple Winer's dilated pores based on late-onset lesions and pathological features. This patient may represent the first case of multiple vulvar Winer's dilated pores. We suggest that electrocautery may be effective for treating this type of superficial entity.

Variants of CARD14 gene and psoriasis vulgaris in southern Chinese cohort

Abstract BACKGROUND: Recent mutation analysis identified several missense mutations in CARD14 in psoriasis. OBJECTIVES: We performed the genomic sequence analysis on CARD14 in southern Chinese Han Cantonese with Psoriasis Vulgaris (PsV) to reveal more causative missense mutations. METHODS: A total of 131 patients with PsV and 207 matched controls were included. We conducted sequence analysis of all the exon and exon-intron boundaries of CARD14 in the group of PsV patients and subsequent case control analysis of potential sequence variants of significance. RESULTS: We found five rare mutations and four of them are annotated or reported. Only the variant (c.1291C>G) has not been reported and annotated, but the variant was also found in controls. No significant difference was detected among all rare variant allele frequencies of patients and controls. CONCLUSION: None of the new definite variants were pathogenic. The other pathogenic mutations for PsV are still elusive in our cohort.

Discussions on the development of biomechanics based on applications and grants of NSFC / 医用生物力学

Biomechanics, one important sub-discipline of mechanics, is an interdisciplinary subject involved in mechanics, biology and medical science, and it is closely associated with life health and clinic medicine. In this paper, applications and grants of normal projects and youth science foundation projects of National Natural Science Foundation of China (NSFC) on biomechanics from year 2012 to 2016 are introduced. Research directions and research teams of biomechanics are mainly discussed, and some suggestions are given for the development of biomechanics in China.

First case of congenital idiopathic hypohidrosis in China

AbstractA 43-year-old Chinese man presented with generalized hypohidrosis, which he had had since birth, without obvious abnormalities of other skin appendages except a sparse beard and axillary hairs. The sweat test revealed localized sweating on the face, axillae and palms. Histopathologic examination showed that the sweat glands were absent in the forearm and thigh, but some eccrine and apocrine sweat glands were present in the right axilla. S-100 was expressed in the nerve terminals surrounding the acini and ducts of the eccrine sweat glands, while PGP9.5 was positive in the acini of apocrine glands and the nerve terminals surrounding the eccrine glands in the axilla. To our knowledge, this is the first case of congenital idiopathic hypohidrosis in China.

A cross-sectional study of the association of movement disorders, constipation and sleep disturbances among elderly in China / 中华预防医学杂志

<p><b>OBJECTIVE</b>To investigate the current status and association between movement disorders, constipation and sleep disturbances in the elderly population of China.</p><p><b>METHODS</b>A total of 42 353 subjects aged over 60 years old from Chinese Chronic Non-communicable Disease & Risk Factor Surveillance (2010) was selected in our study. The information on movement disorders, constipation and sleep disturbances was collected by standardized questionnaire interview. The prevalence and association of self-reported movement disorders, constipation and sleep disturbances was measured according to different gender, age groups and regions.</p><p><b>RESULTS</b>The study was conducted among 42 353 old adults, including 21 893 males (51.7%) and 20 460 females (48.3%); 17 917 from urban areas (42.3%) and 24 436 from rural areas (57.7%); and the proportion of elderly from eastern, central and western regions were 37.9% (16 031 subjects), 29.1% (12 345 subjects) and 33.0% (13 977 subjects) respectively. After weighted complex analysis, the data showed that among the elderly population over 60 years old in China, the self-reported rates of movement disorders, constipation and sleep disturbances were all age-related, rising up with the age increasing. The rates of 60-64 age group were 2.8% (95%CI:1.9%-3.7%), 3.6% (95%CI:3.1%-4.1%) and 12.4% (95%CI:11.0%-13.8%);and in ≥ 80 age group, the rates were 13.2% (95%CI:10.2%-16.1%), 8.8% (95%CI:7.1%-10.6%) and 19.1% (95%CI:16.3%-21.9%). The self-reported rate of movement disorders was 5.7% (95%CI: 4.5%-7.0%); the prevalence of constipation was 5.1% (95%CI: 4.4%-5.7%), which was higher among women (5.8%, 95%CI: 5.0%-6.6%) than it among men (4.3%, 95%CI: 3.7%-4.8%) (χ(2) = 23.40, P < 0.05), and higher among subjects from urban areas (6.0%, 95%CI: 5.1%-7.0%) than from rural areas (4.6%, 95%CI: 3.8%-5.4%) (χ(2) = 5.62, P < 0.05); the prevalence of self-reported sleep disturbances was 14.2% (95%CI: 12.7%-15.8%), higher in women (17.4%, 95%CI: 15.4%-19.3%) than in men (11.0%, 95%CI: 9.7%-12.2%) (χ(2) = 172.05, P < 0.05); the prevalence of movement disorders in people with constipation (16.3%, 95%CI: 12.7%-19.9%) was much higher than it in people without constipation (5.2%, 95%CI: 4.0%-6.3%) (χ(2) = 242.73, P < 0.05); and the prevalence of movement disorders in people with sleep disturbances (13.0%, 95%CI: 10.6%-15.4%) was much higher than it in people without sleep disturbances (4.5%, 95%CI: 3.5%-5.5%) (χ(2) = 688.80, P < 0.05).Logistic regression analysis showed that constipation and sleep disturbances would increase the risk of movement disorders, with the OR (95%CI) at 2.93 (2.57-3.33) and 2.73 (2.48-3.02), respectively.</p><p><b>CONCLUSION</b>The present study showed that self-reported rates of movement disorders, constipation and sleep disturbances all rose up with age increasing in the elderly. The movement disorders was associated with constipation and sleep disturbances.</p>

Androgen deprivation therapy for prostate cancer: a follow-up study of the patients' survival time / 中华男科学杂志

<p><b>OBJECTIVE</b>To explore the long-term survival and prognosis of prostate cancer patients after treated by androgen deprivation therapy.</p><p><b>METHODS</b>We conducted a follow-up study of 124 patients with prostate cancer treated by androgen deprivation therapy, and compared the survival times of the patients with different pathological grades and clinical characteristics using Kaplan-Meiers survival curves.</p><p><b>RESULTS</b>The mean survival time of the 124 patients after androgen deprivation therapy was 5. 912 years, with the median survival time of 7.81 years. The patients with bone metastases showed a shorter survival time than those with non-bone metastasis (P = 0.04). Pathological grades and PSA levels were not prognostic factors. No significant differences were found in the mean survival time between those died of prostate cancer (n = 35) and those from other factors (n = 23) (P = 0.50).</p><p><b>CONCLUSION</b>Bone metastasis is an important prognostic factor in advanced prostate cancer following androgen deprivation therapy, which is more significantly correlated with the survival time of the patients than tumor grades and clinical classification.</p>

Perioperative treatment of senile benign prostatic hyperplasia patients undergoing transurethral electrovaporization of prostate / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the perioperative treatment of senile patients with benign prostatic hyperplasia (BPH) undergoing transurethral electrovaporization of prostate (TUEVP).</p><p><b>METHODS</b>Totally 131 BPH patients aged 75-88 years underwent TUEVP, general data and past history of illness of the patients obtained before surgery, including their mental state, self-care ability, diseases of the cardiovascular, cerebrovascular and respiratory systems, diabetes mellitus, thyroid diseases and medication, and preoperative routine examinations performed on the functions of the kidneys, lungs, heart and thyroid gland to assess their operation-endurance, chances of complications and perioperative countermeasures.</p><p><b>RESULTS</b>Of the total number of patients, 128 recovered urination and 3 relapsed into urinary retention after withdrawal of the catheter, with 2 restored to health. One patient had to carry the stomal tube because of bladder contraction dysfunction, 2 (1.5%) developed secondary bleeding but recovered after conservative treatment, 1 (0.7%) deep vein thrombus, 1 acute hemorrhagic gastritis (0.7%) and 4 (3.0%) postoperative urinary tract infection, but with no TUEVP syndrome and no complications of the cerebrovascular and respiratory systems. A 3-6 months follow-up showed that IPSS decreased from 25.24 +/- 4.70 to 7.81 +/- 4.12, QOL dropped from 4.51 +/- 0.72 to 1.51 +/- 0.73, and Qmax increased from (10.14 +/- 6.31) ml/s to (18. 14 +/- 4. 12) ml/s.</p><p><b>CONCLUSION</b>By proper perioperative treatment, TUEVP could be safely and smoothly performed in senile BPH patients, with fewer complications and better recovery.</p>

Effection of observation Xinnaoxin capsules in treatment of chronic cerebral circulatory insufficiency / 中国中药杂志

<p><b>OBJECTIVE</b>To observe the therapeutic effect of Xinnaoxin capsules in patients with chronic cerebral circulatory insufficiency.</p><p><b>METHOD</b>Patients with chronic cerebral circulatory insufficiency were divided randomly into two groups: a Xinnaoxin capsules group (n = 60, treated by Xinnaoxin capsules for four 4 weeks), a control group (n = 58, treated by Nimodiping for four weeks). The transcranial doppler (TCD) was used to determined mean velocity (Vm) and auto-viscometer measured hemorheological indices before and after being treated.</p><p><b>RESULT</b>After 4 weeks treatment, the hemorheological indices and mean velocity were obviously improve in Xinnaoxin capsules group (P <0.05), there is significant difference between the effective rate of two groups (88.3%, 70.7%).</p><p><b>CONCLUSION</b>Our study suggest that Xinnaoxin capsules have therapeutic function on chronic cerebral circulatory insufficiency.</p>

Quality of life of epilepsy patients in Zhuang populations in Guangxi Guixi area / 中国医学科学院学报

<p><b>OBJECTIVE</b>To investigate the quality of life (QOL) and its influence factors in epilepsy patients in Zhuang population in Guangxi Guixi area.</p><p><b>METHODS</b>Totally 78 epilepsy patients in Zhuang populations and 60 healthy controls were enrolled, and their QOL was assessed with Quality of Life in Epilepsy Inventory-31 (QOLIE-31). The QOLIE-31 scores of patients between different sexes, anti-epileptic drugs (AEDs) usage, duration of seizure, and seizure types were compared.</p><p><b>RESULTS</b>QOL score was significantly lower in epileptic group (53.9 +/- 8.0) compared with control group (77.0 +/- 7.1) (P < 0.01). No difference was found in QOLIE-31 scores of patients between men and women (P > 0.05). Patients with single AED, shorter duration of seizure, and tonic-clonic seizure had higher QOLIE-31 scores than those with multiple AEDs, longer duration of seizure, and other seizure types (P < 0.01, P < 0.05, P < 0.01, respectively).</p><p><b>CONCLUSIONS</b>QOL is lower in epilepsy patients than normal people in Zhuang populations in Guangxi Guixi area. Medication and seizure type affects the QOL in patients with epilepsy.</p>

Effect of Panax notoginseng saponins on serum neuronal specific enolase and rehabilitation in patients with cerebral hemorrhage / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To observe the effect of Panax notoginseng saponins (PNS) on serum content of neuronal specific enolase (NSE) and function recovery in patients with cerebral hemorrhage (CH) for exploring the therapeutic action of PNS in treating CH.</p><p><b>METHODS</b>Fifty CH patients with their course of disease not more than 5 days were randomly assigned to two groups, 27 in the PNS group and 23 in the control group, all were treated with conventional treatment, while PNS was given additionally to the PNS group. The serum levels of NSE before and after treatment were determined by electrochemiluminescence, and the recovery of patients, including their neuro-function deficit and daily living activity, was assessed according to scoring by the National Institute of Health Stroke Scale (NIHSS) and Barthel Index (BI) respectively.</p><p><b>RESULTS</b>Before treatment, the difference between the two groups in serum NSE content and scores of NIHSS and BI was insignificant (P > 0.05). However, after 3 weeks of treatment, the level of NSE and score of NIHSS were significantly lower, while score of BI was significantly higher in the PNS group than those in the control group respectively (all P < 0.01). In the PNS group, the level of NSE showed a positive correlation with the score of NIHSS (r = 0.757, P < 0.05), and a negative correlation with the score of BI (r = - 0.803, P < 0.05).</p><p><b>CONCLUSION</b>PNS can effectively protect the neuron and promote functional rehabilitation in patients after CH.</p>

Long term survival results in advanced prostate cancer treated with combined androgen blockade / 中华男科学杂志

<p><b>OBJECTIVE</b>To understand long-term survival rate after combined androgen blockade (CAB) in patients with advanced prostate cancer.</p><p><b>METHODS</b>A selected population of 59 patients with advanced prostate cancer were treated with CAB. 28.81% (17/59) of patients had clinical locally advanced disease (stage T3-4N0M0), and 45.76% (27/59) of patients had metastatic disease (stage TxNxM+). Overall, patients were followed for a median of 62 (range 6-136) months.</p><p><b>RESULTS</b>Of the 59 patients with advanced prostate cancer, 3-year, 5-year and 7-year overall survival rates were 79.36%, 61.46% and 49.15%, respectively. The 5-year survival rate were 80.77% and 32.65% for clinical locally advanced disease and metastatic disease. Specifically, men with poorly differentiated prostate cancer had a 5-year survival of only 30% when compared with men with well-differentiated prostate disease who had a 5-year survival of 86.21%.</p><p><b>CONCLUSION</b>Based on these findings, men with poorly differentiated cancer, stage T3c-4NxMx or TxNxM+ and PSA level above 30 microg/L had a high probability of dying from their advanced prostate cancer.</p>