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1.
Chinese Journal of Burns ; (6): 459-462, 2013.
Artículo en Chino | WPRIM | ID: wpr-284077

RESUMEN

Caustic esophageal burn is a common ailment in clinical practice. In some patients, scar stricture was formed in the late stage of injury, and it seriously undermined quality of life of the patients. We adopted various clinical interventions at an early stage in order to relieve and alleviate the formation and development of corrosive esophageal stricture as a result of chemical injury as well as to avoid invasive operations to make it more acceptable for the patients. This article summarized the progress in etiology, pathological changes, identification, early prevention, and surgical management of corrosive esophageal stricture.


Asunto(s)
Humanos , Quemaduras , Patología , Constricción Patológica , Patología , Estenosis Esofágica , Patología , Esófago , Heridas y Lesiones , Patología
2.
Chinese Journal of Cardiology ; (12): 1051-1055, 2012.
Artículo en Chino | WPRIM | ID: wpr-292043

RESUMEN

<p><b>OBJECTIVE</b>To investigate the effects of atorvastatin on parathyroid hormone 1-34 (PTH1-34) induced neonatal rat cardiomyocytes hypertrophy and on the expression changes of small GTP-binding protein (K-Ras) and extracellular signal regulated protein kinases 1/2 (ERK1/2).</p><p><b>METHODS</b>Neonatal rat cardiomyocytes hypertrophy was established with 10(-7) mol/L rPTH1-34 in the presence or absence of 10(-5) mol/L atorvastatin or 10(-4) mol/L mevalonic acid (MVA). Cardiomyocyte diameter was measured by Motic Images Advanced 3.0 software, the synthetic rate of protein in cardiomyocytes was determined by (3)H-leucine incorporation and single-cell protein content was measured by BCA. The concentration of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were determined by ELISA. Protein expression of ERK1/2, p-ERK1/2 and K-Ras was detected by Western blot.</p><p><b>RESULTS</b>Compared to PTH1-34 group, cellular diameter was decreased 12.07 µm, (3)H-leucine incorporation decreased 1622 cpm/well and single-cell protein content decreased 84.34 pg, ANP or BNP concentration reduced 7.13 µg/L or 20.04 µg/L, protein expression of K-Ras, ERK1/2 or p-ERK1/2 downregulated 0.81, 0.19 and 1.44 fold, respectively, in PTH1-34 plus atrovastatin co-treated cardiomyocytes (all P < 0.05). Compared to PTH1-34 plus atrovastatin co-treated group, cardiomyocyte diameter increased 4.95 µm, (3)H-leucine incorporation increased 750 cpm/well and single-cell protein content increased 49.08 pg, ANP or BNP increased 3.12 µg/L or 9.35 µg/L and protein expression of K-Ras, ERK1/2 or p-ERK1/2 upregulated 0.52, 0.06 and 1.19 fold (all P < 0.05) in MVA, PTH1-34 and atrovastatin co-treated cardiomyocytes.</p><p><b>CONCLUSIONS</b>Atrovastatin attenuates PTH1-34 induced neonatal rat cardiomyocytes hypertrophy through downregulating K-Ras and ERK1/2 pathway.</p>


Asunto(s)
Animales , Ratas , Animales Recién Nacidos , Atorvastatina , Cardiomegalia , Quimioterapia , Metabolismo , Células Cultivadas , Ácidos Heptanoicos , Farmacología , Usos Terapéuticos , Sistema de Señalización de MAP Quinasas , Proteína Quinasa 3 Activada por Mitógenos , Metabolismo , Miocitos Cardíacos , Metabolismo , Hormona Paratiroidea , Metabolismo , Pirroles , Farmacología , Usos Terapéuticos , Ratas Wistar
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