Research on distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular based on cluster analysis / 中国中药杂志

To discuss the distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular, the patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular were cluster analyzed by means of simple statistics and cluster analysis. Clustering variables were composed of patent applications, patent maintained number, related papers' quantity, etc. Chinese herbal compound patents' holders were divided into four categories according to their different scientific research and patent strength. It is the magic weapon for Chinese herbal compound patents' holders that have scientific research patents' transforming and make coordination of patent protection and scientific innovation.

Study on influencing factors of valid patents of compound traditional Chinese medicines for cardiovascular and cerebrovascular diseases on base of regression analysis / 中国中药杂志

<p><b>OBJECTIVE</b>To explore the influencing factors for the maintenance of valid patents of compound traditional Chinese medicines in treating cardiovascular and cerebrovascular diseases.</p><p><b>METHOD</b>Logistic regression analysis was used to detect the influencing factors for the maintenance of valid patents.</p><p><b>RESULT</b>The maintenance of valid patents of compound traditional Chinese medicines in treating cardiovascular and cerebrovascular diseases was closely related to many factors, such as their invention, patent rights' transfer, patent claims and patent declaration documents.</p><p><b>CONCLUSION</b>The maintenance of valid patents of compound traditional Chinese medicines in treating cardiovascular and cerebrovascular diseases depends on many factors, such as centralization of efficacy of components of patent compound traditional Chinese medicines, increasing number of dependent claims, and supply of new dosage form and detailed experimental data. Therefore, the transfer of patent rights is of great significance to the maintenance of patents.</p>

Current service invention patents and growth pathways on basis of cluster analysis / 中国中药杂志

This study aims for enhancing quantity and quality of patents of traditional Chinese medicine compounds of traditional Chinese medicine enterprises, traditional Chinese medicine colleges and relevant institutions while building an efficient pathway for patent protection using simple statistics and cluster analysis, with service invention patent holders of traditional Chinese medicine compounds as the study object.

Regularity of drug use of patents in force of traditional Chinese medicine compounds in preventing and treating cardiovascular diseases on basis of frequency analysis / 中国中药杂志

<p><b>OBJECTIVE</b>To study the regularity of drug use of patents in force of traditional Chinese medicine compounds in treating cardiovascular diseases and provide reference for new drug R&D and patent protection.</p><p><b>METHOD</b>With long-lasting patents in force of traditional Chinese medicine compounds in treating cardiovascular diseases as the study object, the frequency analysis was made for studying their core ingredients, efficacy, channel tropism and drug compatibility.</p><p><b>RESULT AND CONCLUSION</b>There are nearly 30 frequently used traditional Chinese medicine compounds in treating cardiovascular diseases with patents in force including Salvia miltiorrhiza and Astragalus mongholicus, with main efficacy for promoting blood circulation and removing blood stasis and reinforcing Qi and the highest efficacy in heart, liver, spleen and lung channels. The results of this study provide reference and new room for development for R&D of traditional Chinese medicine compounds in treating cardiovascular diseases and patent protection.</p>

GC-MS analysis of essential oil from anthodiums of Chrysanthemum morifolium processed by microwave-airflow and steam calefaction / 中国中药杂志

<p><b>OBJECTIVE</b>Analysis of the constituents of the essential oil extracted from the flowers of the Chrysanthemum morifolium processed by the microwave-airflow and the calefaction after steam process from the State Chrysanthemum GAP bases in Zhejiang Province and to provide scientific basis for quality control.</p><p><b>METHOD</b>The essential oil was extracted by water-steam distillation and separated by GC capillary column chromatography. The components were quantitatively determined with normalization method, and identified by GC-MS.</p><p><b>RESULT</b>From the microwave-airflow dried sample and the calefactively dried sample after steam process, 119 and 175 components were detected, among them fifty and fifty-five components were identified, which were composed of 67.89% and 63.64% of the total essential oil, respectively.</p><p><b>CONCLUSION</b>The yield of the essential oil extracted from the microwave-airflow dried sample was 0.40%, and that from the calefactively dried sample after steam process was 0. 19%. The former is 2.1 times higher than the latter. The components of the essential oil are similar and there are differences between the content of corresponding compounds in the two samples. The results showed that application of microwave-airflow combined drying technology remained original and essential constituents. The production benefit was improved greatly. The grade and quality of C. morifolium enhanced, and it's market selling price was increased compared to the traditional drying calefaction after steam process.</p>

GC-MS analysis of essential oils from Radix Angelicae Pubescentis / 中国中药杂志

<p><b>OBJECTIVE</b>To analyze the constituents of the essential oils from Radix Angelicae Pubescentis planted in a GAP base of the Chinese medica materials, and provide the scientific basis for quality control.</p><p><b>METHOD</b>The essential oils were extracted by water-steam distillation and separated by GC capillary column chromatography. The components were calculated with normalization method, and were identified by MS detector.</p><p><b>RESULT</b>229 peaks weredetected, among which 8 compounds have been identified, which made up 78.23% of the total essential oil.</p><p><b>CONCLUSION</b>In the total essential oils of Radix Angelicae Pubescentis, 3-carene (8.89%), m-cymene (4.99%) and beta-phellandrene (8.35%) as the monoterpenes and its derivatives, and eudesma-4 (14), 11-diene (4.36%), alpha-selinene (1.36%), ledol (1.14%), alpha-bisabolol (6.03%), and 1, 8-dimethyl-4-(1-methylethyl)-spiro[4.5]dec-8-en-7-one (4.37%) as the sesquiterpenes and its derivatives, are main components.</p>