Risk factors of intracranial hemorrhage with 125I seeds for the treatment of brain tumors / 中华内科杂志

Objective:To analyze the risk factors of intracranial hemorrhage after implanting 125-iodine seeds for brain tumors.Methods:A total of 234 patients with intracranial tumors receiving treatment of 125-iodine seeds from March, 2013 to November, 2020 were retrospectively analyzed. Patients were divided into bleeding group and non-bleeding group according to whether postoperative intracranial hemorrhage was reported. Univariate and multivariate analysis was performed by logistic regression to determine the independent risk factors of intracranial hemorrhage.Result:A total of 22 cases (9.4%) reported postoperative intracranial hemorrhage in 234 patients treated with 125-iodine seeds. Univariate analysis showed that the type of tumor and the history of anti-angiogenic drug within one month were possible risk factors ( P<0.1). Multivariate logistic regression analysis showed that anti-angiogenic drug within one month was the independent risk factor for intracranial hemorrhage ( P<0.05). Conclusions:The application of anti-angiogenic drugs within one month is the independent risk factor of intracranial hemorrhage with 125-iodine seeds for the treatment of brain tumors.

Effects of survivin gene silencing by small interfering RNA on apoptosis of oral squamous cell carcinoma / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To apply the small interfering RNA (siRNA) targeting survivin to inhibit expression of survivin gene in HSC-3 oral squamous cell carcinoma and to increase the apoptosis of HSC-3 cells.</p><p><b>METHODS</b>siRNA was synthesized and transfected into oral squamous cell carcinoma HSC-3 cells. Compared with negative control group and blank control group, semi-quantitive reverse transcription-polymerase chain reaction (RT-PCR) was used to detect survivin mRNA. Cellular viability was detected by MTT and HSC-3 cell apoptosis was determined by tunnel and flow cytometry.</p><p><b>RESULTS</b>Expression of survivin mRNA was decreased significantly in siRNA group compared with negative control group and blank control group. Cellular viability was not affected in negative control group and blank control group, but cellular viability in siRNA group was significantly decreased. As to the cellular apoptosis rate, the transfected group (24.99% +/- 1.33%) was significantly higher than negative control group (1.24% +/- 0.13%) and blank control group (0.10% +/- 0.02%).</p><p><b>CONCLUSION</b>Survivin gene silenced by siRNA might promote apoptosis of oral squamous cell carcinoma. Survivin siRNA gene therapy would become a new target point for oral squamous cell carcinoma.</p>

Analysis of Volatile Components from the Flowers of Gypsophila oldhamiana by Head-space Solid Phase Microextraction Coupled with GC-MS / 中国药房

OBJECTIVE: To analyze the volatile constituents from the flowers of Gypsophila oldhamiana. METHODS: The volatile components were analyzed by head-space solid phase micro-extraction coupled with GC-MS. RESULTS: 18 compounds were identified from G. oldhamiana, accounting for 87.52% of the total volatiles, among which 1-Hexanol accounted for 20.32%, followed by dimethylsulfide (10.30%),2-ethyl-furan (9.44%),nonanal (6.84%),3-methyl-butanal(6.33%). CONCLUSION: The study can provide scientific basis for the further development of the flowers of G. oldhamiana.