Low expression of cystic fibrosis transmembrane conductance regulator gene allele IVS8-5T may be associated with decreased prostate cancer risk / 肿瘤研究与临床

Objective To investigate the association between functional polymorphism IVS8-poly (T) in cystic fibrosis transmembrane conductance regulator (CFTR) gene and prostate cancer risk.Methods A population-based case-control study was conducted including 230 prostate cancer patients and 230 agematched controls.PCR-STRP was used to analysis the IVS8-poly (T) tract in CFTR gene.Results The prevalences of the low expression allele,the IVS8-5T,in prostate cancer patients and controls were 1.52 ％ (7/460) and 5.22 ％ (24/460),respectively (x2 =12.489,P =0.002).Logistic regression analysis confirmed the 5T/7T genotype was in protective association with prostate cancer risk (OR =0.232,P =0.003,95 ％ CI0.090-0.599).Conclusion The low expression CFTR IVS8-5T allele contributes to a reduced risk of prostate cancer in Chinese Han population,and may be a protective factor against prostate cancer.

Drugs Therapeutic Care and Avoidance of Adverse Drug Reactions of Antitumor Drugs / 中国药房

OBJECTIVE:Due to the development of pharmacy and biotechnology,epidermal growth factor receptor(EGFR) and vascular endothelial growth factor(VEGF)have been regarded as the target sites in the attack against tumor cells,leading to the shift of drug treatment focus from cellular level to molecular level and enhancing curative effects of combined therapy of tumor. This paper summarized its advantages and pharmaceutical cure. METHODS:Medical literatures in recent years at home and abroad were collected and analyzed. RESULTS&CONCLUSION:Large numbers of indication-based medical studies have proved that antithrombotic drugs have good efficacy,but rational use of antithrombotic drugs is very important,especially the avoidance of adverse drug reactions of antitumor drugs.

Pharmaceutical Care in the Therapy of Anticoagulant and Antiplatelet Drug / 中国药房

OBJECTIVE: To summarize the advantage and pharmaceutical care of antiplatelet drug because antiplatelet drug has satisfactory effect on thrombotic disease and platelet disorder with rapid development and sound clinical utilization and evaluation. METHODS: Literature review method was adopted to analyze medical literatures at home and abroad. RESULTS&CONCLUSION: In the large number of clinical studies, anticoagulant and antiplatelet drug have sound efficacy. Therefore it is important to use anticoagulant and antiplatelet drug rationally and safely.

National Formulary Interpretation / 中国药房

OBJECTIVE:To analyze and summery the characteristics and clinical guiding significance of National Formulary?The Part of Chemicals and Biological Products(2010 version).METHODS:Literatures at home and abroad were retrieved and literature review method was applied for analysis.RESULTS&CONCLUTION:National Formulary?The Part of Chemicals and Biological Products(2010 version) includes four parts,i.e.general part,special part,national appendix and index.It represents as authority,guideline and Chinese characteristics as well as cultural and distribution characteristics professionally.Comprehensive and typical National Formulary is also characterized with timeliness because it is revised regularly.It had been written scientifically and freely and serves as standard for clinical drug use to improve diagnostic and therapeutic level,safety and development of drug use.

Model Establishment and Standardization of Medication History in China / 中国药房

OBJECTIVE:To discuss the model establishment and its standardization of medication history in China.METHODS:The model establishment and standardization of medication history in China was discussed by case study and reviewing of pertinent literatues both at home and abroad.RESULTS & CONCLUSIONS:Medication history came into being because of the demand of pharmaceutical care,and which is the important document in the pharmaceutical services and pharmacists' intervention thus posing significant practical value.The medication history that tailored to Chinese condition will be formed and improved in the future.

Responsibility Transformation of Pharmacists and Its Necessity / 中国药房

OBJECTIVE: To discuss the responsibility transformation of pharmacists and its necessity.METHODS: The process of transformation in fundamental responsibility of pharmacists were reviewed; the current situation in the development of pharmacist group was presented, and the necessity to transform the responsibility of pharmacists was analyzed.RESULTS&CONCLUSION: It is the contemporary demand to transform the responsibility of pharmacists in China.Training of pharmacy talents and the development in the field of pharmacy, construction of information system, the development and utilization of information, scientific research, the development and utilization of new technology and method, as well as the strengthened management of drug distribution chain, and the establishment of Pharmacist Law can all help to achieve a full range of pharmaceutical care.