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BACKGROUND:During intervertebral disc degeneration,mitophagy plays an extremely important role in preventing the progression of intervertebral disc degeneration.Regulating the level of mitophagy may be a new strategy for the treatment of intervertebral disc degeneration. OBJECTIVE:To review the relationship between mitophagy and intervertebral disc,in order to provide a reference for the treatment of intervertebral disc degeneration by regulating the level of mitophagy. METHODS:A literature search was performed in CNKI,Wanfang,VIP,and PubMed using"intervertebral disc degeneration,mitophagy,targeted therapy,inflammation,signaling pathways"as Chinese and English search terms.Finally,54 articles were included and summarized. RESULTS AND CONCLUSION:(1)At present,the specific mechanism of intervertebral disc degeneration is not clear.A large number of studies have shown that intervertebral disc degeneration is closely related to mitophagy,which involves a relatively complex mechanism and pathway.Among various pathways,PINK1/Parkin is the most widely studied signaling pathway for mitophagy regulation.(2)Some drugs,such as Salidroside,Urolithin A,Honokiol,MitoQ,have been found to have the potential to treat intervertebral disc degeneration by regulating the level of mitophagy.These drugs have shown positive preclinical results.(3)At present,the targeted therapy of mitophagy is mainly preclinical research and has achieved positive results.Further clinical research is needed to explore its clinical efficacy and safety.
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Objective:To investigate the application of the decision-oriented context-input-process-product (CIPP) model combined with integrated teaching in standardized training of medical oncology.Methods:A total of 98 standardized training residents who participated in standardized training in Department of Oncology, Jiangsu Cancer Hospital, were enrolled as subjects, and they were divided into control group and observation group using a simple random number table, with 49 residents in each group. The residents in the control group received routine teaching, and those in the observation group received CIPP model combined with integrated teaching. The two groups were compared in terms of department examination score and assessment of subjective learning effect, and the observation group was assessed in terms of critical thinking ability before and after training. SPSS 22.0 was used for the t-test. Results:Compared with the control group, the observation group had significant increases in theoretical examination score ( t=2.95, P=0.004), practical operation score ( t=17.04, P<0.001), and total score ( t=3.55, P=0.001). After training, the observation group had significant increases in the scores of each dimension of critical thinking ability and the total score of critical thinking ability ( t=2.89, 3.55, 3.37, 3.20, 3.13, 2.67, 3.06, 3.13; P=0.005, 0.001, 0.001, 0.002, 0.002, 0.009, 0.003, 0.002). The observation group had significantly higher assessment scores of subjective learning effect than the control group ( t=3.46, 3.56, 2.83, 2.85, 2.57, 3.07; P=0.001, 0.001, 0.006, 0.005, 0.012, 0.003). Conclusion:The CIPP model combined with integrated teaching can improve the department examination score and critical thinking ability of standardized training residents in medical oncology, with good assessment results of subjective learning effect.