RESUMEN
The activities of interleukin 6 (IL 6) and tumor necrosis factor alpha (TNF?) produced by peripheral blood mononuclear cells (PBMCs) in vitro and their relevant levels in sera were measured in 49 patients with psoriasis vulgaris (PV) and in 20 normal controls using bioassay. The relationship between them was also analysed. The results showed that in PV patients the activites of IL 6 and TNF? produced by PBMCs and their serum levels were higher than those in healthy controls. There was a positive linear correlation between the activites in vitro and relevant levels in sera, and a positive linear correlation between serum levels of IL 6 and TNF?. These results indicate that there is dysfunction of cellular immune of PBMCs in PV patients. The increase of serum levels of IL 6 and TNF? may be related to the increased activity of PBMCs, and there may be a synergic action between IL 6 and TNF? in the pathogenesis of psoriasis.
RESUMEN
Abstract In this paper,the sequences of second exon of DQA1 and DQB1 were amplified byPCR primers,and hybridized with 17 or 23 sequence specific oligonucleotide probes labeled byisotope respectively.The distribution of 10 DQA1 alleles and 17 DQB1 alleles was observed inHunan Hans population.The results showed that the most of DQAI and DQB1 alleles were ex-pressed in Hans,however,their frequencies are different from Caucasoids.
RESUMEN
Transforming growth factor type ?1(TGF—?1)belong to a family of polypeptides with regulato-ry effects on growth and differention of a variety of cells types.TGF—?1 play an important rolein regulation of immune response by acting as a negative modulate the cell proliferation throughstill unknow mechanisms.We investigated the effect of TGF—?1 on the IL—2R expression andproliferation activited DN cells and we observed that TGF—?1 was able to increase the expres-sion of IL—2R in DN cells and to suppress the proliferation of DN cells and we have discussedabout these results.