RESUMEN
Capacity of the binding and cytolysis of Ehrlich ascites carcinoma (EAC) by peritoneal Macrophages from tumor-bearing mice (TPM) and peritoneal macrophage from normal mice (NPM) was studied in present experiment.NPM and TPM treated with LPS enhanced binding of neoplasic cell but failed to kill target cells.TG-induced M? had little capacity to cytolysis of target cells.Exposure of TG-induced M? to LPS activated M? which could kill tumor cells efficiently and increased binding capacity as compared with TG-induce M? without activation by LPS.The activity of binding and cytolysis of TPM treated with activator is lower than that of NPM treated with same activator.When the concentrations of M? and target cells were altered respectively,the kinetics of binding correspond with that of cytolysis.It shows that capacity the binding and cytolysis of neoplastic cells is suppressed even if the activator is added.