Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
1.
Chinese Journal of Hepatology ; (12): 46-48, 2002.
Artículo en Chino | WPRIM | ID: wpr-257889

RESUMEN

<p><b>OBJECTIVE</b>By clarifying the natural history of chronic hepatitis B, to evaluate its long-term therapeutic outcome, antiviral drugs efficacy and economic significance.</p><p><b>METHODS</b>A cohort of 183 (mean age of 31.75?.03 years, male/female ratio: 152:31) chronic hepatitis B patients with biopsy-proven and 247 cases of general population as control were followed up by retrospective cohort study. The follow-up time was 11.81?.08 years. This study was focused on long-term clinical outcome including the rate of liver cirrhosis, hepatocellular carcinoma and death, the long-term effect of antiviral drugs and prognostic factors.</p><p><b>RESULTS</b>In chronic hepatitis B patients, 22 (12.02%) developed liver cirrhosis, 12 (6.56%) hepatocellular carcinoma, and 20 (10.93%) died. The cumulative survival probabilities were 97.27%, 91.62%, and 84.47% in 5, 10, and 15 years, respectively. The cumulative probabilities of HCC were 0.00%, 3.19%, and 11.56% in 5, 10, and 15 years, respectively. In 247 control subjects, 6 (2.43%) died, none of them developed cirrhosis or HCC. The rates of death, liver cirrhosis, and HCC in hepatitis B patients were markedly different (P<0.005) compared with controls. The overall mortality of hepatitis B patients was 4.50 folds of the general population. Cox multiple regression analysis showed that old age, severe histological injury, and the positive HBeAg were closely related to liver cirrhosis, while old age, severe histological injury, and male were major factors leading to death. The independent variable of predicted HCC was not found.</p><p><b>CONCLUSIONS</b>The long-term outcome of hepatitis B is poor.</p>


Asunto(s)
Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Envejecimiento , Fisiología , Carcinoma Hepatocelular , Epidemiología , Estudios de Cohortes , Estudios de Seguimiento , Antígenos e de la Hepatitis B , Fisiología , Hepatitis B Crónica , Epidemiología , Mortalidad , Cirrosis Hepática , Epidemiología , Fallo Hepático , Neoplasias Hepáticas , Epidemiología , Análisis de Regresión , Estudios Retrospectivos , Factores de Riesgo , Sexo , Tasa de Supervivencia
2.
Chongqing Medicine ; (36): 6-7,10, 2001.
Artículo en Chino | WPRIM | ID: wpr-556229

RESUMEN

Objective we studied the effect of the Purine mucleoside Valaciclovir on anti-duck hepatitis virus(DHBV) in vivo to provide an experimental basis for clinical treatment of patients with hepatitisB.Methods The Chongqing duck hepatitis B virus model was treated with Valaciclovir once a day for a month at the doses of 50mg.kg-1、100mg.kg-1、200mg.kg-1of body weight per day. Serum DHBV DNA was detected four times in the course of the treatment,ALT and AST in serum and DHBV DNA in liver were detected simultaneously.Results Valaciclovir could signsificantly lower the serum DHBV DNA level. Serum ALT of several ducks in serum rose slightly during the treatment,but became normal after 1 week stopping Valaciclovir. Examination of DHBV DNA in liver with Southern Blot indicated Valaciclovir could inhibit DHBV DNA replication,but could not completely eliminate DHBV SC DNA.Conclusion The study confirms the safety and potent antihepaticviral activity of Valaciclovir in vivo.

3.
Chinese Traditional Patent Medicine ; (12)1992.
Artículo en Chino | WPRIM | ID: wpr-573174

RESUMEN

AIM: The residues of BHC, DDT and PCNB in traditional Chinese preparations made in Fuzhou, Zhangzhou, Xiamen and Jianyan districts were determined. METHODS: Nine kinds of organochlorine pesticides were determined by gas chromatography. RESULTS: BHC in sample determined is under 0.1 mg?kg -1, DDT≤0.1 mg?kg -1, PCNB≤0.1 mg?kg -1. CONCLUSION: The residual determination of organochlorine pesticides in traditional Chinese preparation conforms to the criterion.

4.
Acta Anatomica Sinica ; (6)1953.
Artículo en Chino | WPRIM | ID: wpr-569078

RESUMEN

The mucosal surface of the digestive tract of Ophicephalus argus Cantor was observed with scanning electron microscope. The ultrastructural features of buccopharynx, oesophagus, stomach and intestine were observed. There are many microridges on the surface of mucosal cells of the buccopharynx and oesophagus. On the surface of mucosal cells of the stomach and intestine exist many microvilli, and numerous goblet cells located in the mucosal epithelium of the buccopharynx, oesophagus and intestine. These structural features may be related to feeding habits of Ophicephalus; argus.

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA