Severe diabetic ketoacidosis precipitated by an atypical antipsychotic drug

We report a young Kuwaiti gentleman who presented with severe diabetic ketoacidosis [DKA] associated with atypical antipsychotic drug olanzapine. The current medical literature suggests that atypical antipsychotic drugs, including olanzapine lead to weight gain, insulin resistance, impaired glucose tolerance, diabetes mellitus [DM] and rarely patient may present with serious side effects like DKA. Clinicians are urged to monitor the emergence of metabolic risk factors periodically and remain aware of potentially serious effects like DKA in schizophrenic patients taking olanzapine

Moyamoya syndrome with primary antiphospholipid syndrome

To report a rare case of moyamoya syndrome with primary antiphospholipid syndrome [APS]. A 41-year-old woman was admitted with sudden onset of left-sided hemiparesis. Magnetic resonance imaging and magnetic resonance angiography of the brain showed characteristic features of moyamoya vessels. Laboratory investigations revealed raised levels of anticardiolipin antibody. She made a complete and uneventful recovery with aspirin and intensive physiotherapy over a period of 2 weeks. The association of APS and moyamoya disease may present a dilemma in management. While APS is often considered to be an indication for giving anticoagulation, a trial of antiplatelet agents is preferable to anticoagulation because of the risk of bleeding from the fragile moyamoya vessels

Autoimmune thyroid disease in a patient with Usher's syndrome: case report

Usher's syndrome [US] is a rare genetic disorder characterized by congenital sensorineural deafness arid retinitis pigmentosa. Here, we describe the association of US and hypothyroidism due to autoimmune thyroid disease [AITD] in a 50-year-old Kuwaiti woman diagnosed clinically to have US. As far as we are aware, this is the first case report of US in Kuwait arid to our knowledge the association with AITD has not been previously reported