RESUMEN
The aim of this study was to Investigate the relationship between metabolic risk factors and oxidative stress using urinary 8-hydroxydeoxyguanosine [8-OHdG], a recently utilized biological marker, in asymptomatic subjects. Ninety subjects [males/females = 30/60; mean age = 52 years], who were nonsmoking, nondiabetic and not on any medicine, were enrolled in the study. The body mass index, blood pressure, total cholesterol, triglyceride [TG], high-density lipoprotein cholesterol [HDL-C] and glucose as well as urinary 8-OHdG and creatinine were measured. The median level of 8-OHdG was 9.3 ng/mg creatinine [nterquartile range: 5.8-23.2]. TG [Pearson's correlation: r = 0.262, p - 0.013] and HDL-C [r - -0.259, p - 0.014] showed a significant correlation with 8-OHdG. A multiple linear regression analysis adjusted for all the variables revealed that only TG had an independently significant and positive correlation with 8-OHdG [p = 0.231, p = 0.046]. The data in this population suggest that, among metabolic risk factors, hypertriglyceridemia may be weakly but significantly associated with hyperoxidative stress as assessed by 8-OHdG