RESUMEN
Objective To study the possible protective mechanisms of Anisodamine against liver injury induced by hemorrhage shock(HS). Methods In this study, we established animal models induced by HS and endotoxin, observed the expressions of NF-?B mRNA and heat shock protein 70(HSP 70) mRNA by In-situ hybridization (ISH) in liver kupffercells(KC) and studied the pathologic changes of the liver tissue by microscope. Results After stimulus of HS and injection of endotoxin, the mRNA expressions of HSP70 and NF-?B in KC were (0.1565?0.0260) and (0.1659?0.0103),respectively, and significantly higher than those in the control group (0.0328?0.0201; 0.0256?0.0043)(P
RESUMEN
74 cases of the aged severe craniocerebral injury were presented in this paper, which accounts for 11.9% of the severe craniocerebral injury for the period. Among them, 28 cases died with a morta-lity of 37.8%. The mortality amounts to 51.4% in intracranial hematoma cases. 5 cases over 70 years all died. The reaction capacity becomes lower in old people, so that in craniocerebral injury the early clinical manifestations are difficult to represent the truth.Close observation and the early accurate diag-nosis are rather important. Attention should be paid to the multiple injuries and severe medical con-ditions. Some factors such as early clearance of the intracranial hematoma and prevention of com-plications and hypotension during an operation may reduce the mortality.Prognosis may be affected by such factors as the severity of the primary, injury, the compound injuty, complications, age and the deficiency in cerebral blood supply after cranio-cerebral injury.