Pro-Convulsant Effect of Olanzapine, an Atypical Antipsychotic on Maximal Electro Shock Induced Seizures in Wistar Albino Rats.

Objectives: The aim of the study was to investigate the chronic effect of Olanzapine; an atypical antipsychotic drug on maximal electroshock (MES) induced seizures in Wistar albino rats. Methods: Olanzapine (2mg/kg, 10 days orally) was used to study its effect on MES induced seizures in Wistar albino rats. Duration of the tonic hind limb extension was noted. Results: Olanzapine (2mg/kg) significantly (p<0.001) increased the duration of hind limb extension induced by MES. Conclusions: The data suggests that Olanzapine, the atypical antipsychotic drug has a proconvulsant action.

Effect of Ethanolic Extract of Phyllanthus Amarus and Tylophora Indica on Isoniazid Induced Hepatic Injury in Wistar Albino Rats.

Objective: To assess the hepatoprotective effect of ethanolic extract of leaves and stem of Phyllanthus amarus and ethanolic extract of leaves of Tylophora indica against Isoniazid induced liver toxicity in experimental animals. Methods: Liver toxicity was induced by administering Isoniazid 27mg/kg orally for 30 days in Wistar albino rats. Ethanolic (90%) extracts of Phyllanthus amarus (PAEE) and Tylophora indica (TIEE) was administered orally to the experimental animals for 30days. The hepatoprotective activity of the extracts was assessed by analyzing the levels of various biochemical parameters like Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ‐Glutamyl transferase (GGT), total bilirubin (TBL) and albumin (ALB) in serum. Mean while the levels of antioxidant enzymes like Superoxide dismutase (SOD), Catalase (CAT), Reduced glutathione (GSH) were measured in rat liver homogenate. Results: The results showed that on administration of Isoniazid for 30 days caused a significant increase (p<0.001) in the levels of ALT, AST, ALP, GGT, TBL in serum. At the same time, the serum level of ALB was significantly (p<0.01) reduced in Isoniazid administered rats. The levels of SOD, CAT and GSH in liver homogenate were also decreased significantly (p< 0.01) in Isoniazid administered animals. The levels of above biochemical parameters were significantly (p< 0.001) reversed in rats which received PAEE and TIEE. Conclusion: The present study proves that the ethanolic extracts of Phyllanthus amarus and Tylophora indica have a significant protective action against isoniazid induced hepatic injury.