RESUMEN
Objective: To compare frequency of Hyperprolactinemia with Risperidone and Olanzapine in patients with first episode psychosis
Study Design: Randomized controlled trial
Place and Duration of Study: Combined Military Hospital [CMH] Lahore, over a period of six months from Sep 2015 to Feb 2016
Subjects and Methods: Total 60 patients who had psychosis as accompanying feature in any of the various psychiatric illnesses according to ICD-10 diagnostic criteria were enrolled in this Randomized controlled Trial. Fasting venous blood samples for serum prolactin were collected between 0800 hrs and 1000 hrs at baseline [first visit]. The patients were then randomly assigned to receive risperidone or olanzapine by lottery method. Serum prolactin levels were then collected at 3 months follow-up visit. All samples were tested in labortary of Pathology department, CMH Lahore for measurement of serum prolactin levels and results were verified by a classified pathologist. Confounding variables were identified and excluded by exclusion criteria
Result: A total of 35 patients [58.33 percent] developed hyperprolactinemia. The olanzapine group showed 13 out of 30 patients [43.33 percent] and risperidone group showed 22 out of 30 patients [73.33 percent] with raised prolactin levels with p-value of 0.018 indicating that the difference was statistically significant
Conclusion: Frequency of hyperprolactinemia is high with risperidone than with olanzapine in first episode psychosis