RESUMEN
Salmonella infections are an important cause of mortality and morbidity in cattle, and subclinically infected animals arefrequently found. The microorganism may exhibit multiple antibiotic resistance and may be able to survive in harsh environmentssuch as the gallbladder. Salmonella Multiple Antibiotic Resistance (MAR) was detected in bile and gallbladder epitheliumfrom cattle slaughtered in a plant in southern state of Rio de Janeiro, Brazil, under sanitary conditions. The frequency ofresistance to each drug was not significantly different between bile and epithelium, except in the case of cefotaxime, whichshowed increased resistance in the bile. Aztreonam was the most effective antibiotic for inhibiting strain growth. Since theresults showed Salmonella spp. strains resistant to twelve antimicrobials, it denotes an alarming risk, therefore in cases ofinvasive infections in both human and animals there will be reduction of therapeutic options against the pathogen.