RESUMEN
The disabling mental illness anxiety is gradually affecting the modern society in any age group worldwide. The searchfor novel bioactive entity from herbal origin for different disorders has become the center of attraction significantlyfrom the past few decades. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter known tobe responsible for the anxiolytic activity of most of the potent anxiolytic agents. All the available data of pongamol1-(4-methoxybenzofuran-5-yl)-3-phenylpropane-1, 3-dione (MPD) were based on natural or semi-synthetic source.The synthetic routes were using easily available source and quick, cost-effective, and high yielding process. MPD hastraditionally been acquired from natural sources mainly from the extracts of fruits of Pongamia pinnata and Pongamiaglabra, where the yield value and the yield time are the main drawbacks. Keeping in view of the above aspects in thepresent research, it was approached to synthesize and evaluate the anxiolytic potential 1-(methoxybenzofuran-5yl)-3-phenylpropane-1, 3-dione on experimental animals and docking procedure after its synthesis. The study of MPDon the gross behavior of mice showed a significant Central Nervous System (CNS) depressant effect. Furthermore,its anxiolytic activity was confirmed by observing its reduced locomotion of mice using actophotometer and elevatedplus-maze apparatus. The highest docking score was observed to be −3.22 than the diazepam (−3.21) against GammaAmino Butyric Acid-A (GABAA). The present study provides a promising anxiolytic agent, MPD, which has itspotency due to the GABAA receptor binding and causing the mitigation of the symptoms of anxiety.
RESUMEN
Background:Coronary Artery Disease being the leading cause of death in patients with Type 2 Diabetes Mellitus often may remain asymptomatic due to silent Myocardial ischemia. People suffering from diabetes mellitus have 2-4 times higher risk of developing coronary artery disease. In such patients periodical clinical examinations and resting ECG may not detect the impending coronary artery disease. Therefore, we analysed the diagnostic utility of Treadmill Test in predicting Silent cases of Myocardial Ischemia. Methods: Our study was conducted as an Observational study over a period of 1.5 years including 50 patients of Type 2 Diabetes Mellitus. This study was conducted at a tertiary care centre of Western Uttar Pradesh. Results: The results of Treadmill test demonstrated that amongst the studied cases of Type 2 diabetes mellitusapproximately one-third of the cases showed positive association whereas the rest were negative. These positive TMT cases were associated with longer duration of Type 2 Diabetes Mellitus. In this study we also evaluated possible association between Autonomic Dysfunction with Positive Treadmill Test. Conclusion: Our study concluded that Screening for Coronary Artery Disease should be done in all Type 2 Diabetes Mellitus patients with prolong duration of Diabetes and with Autonomic Neuropathy. As it will lead to early detection of Coronary Artery Disease and its management will reduce the morbidity and mortality due to the same.