RESUMEN
Background: PCOS patients who fail to respond to CC are considered as clomiphene resistant. Approximately 15%–40% of women with PCOS, it is very common. Obesity, insulin resistance, ( 50%–70% of females with PCOS) and hyperandrogenemia are some major factors which postulated for CC resistance. Methods: In this study 50 females were included on the basis of inclusion and exclusion criteria. The duration of study was over a period of 3 month. This study was conducted in the Department of Gynecology, K M Medical College & Hospital, Mathura Result: This result revealed that 56% cases had elevated LH, 36% had hypothyroidism followed by 16% hyperprolactinemia & 4% hypoprolactinemia. Conclusion: This study suggested that, Obesity and overweight are the most important modifiable risk factor which causes 70% of cases to prevent PCOS, weight reduction is one of the most important step.