RESUMEN
Background: Infertility effects more than 180 million people world-wide and couples should be evaluated to focus on the modifiable factors and various interventions to optimize the results before switching to costly treatments. Artificial insemination husband is one such treatment where various prognostic factors determine the success.Methods: The present study was done in department of reproductive medicine and surgery GSL medical college .All infertile couples attending the clinic and satisfying inclusion and exclusion criteria after proper consent were enrolled for study. Various relevant prognostic factors determining outcome were analysed statistically using the chi square test, the Fischer exact test, and the one way ANNOVA test.Results: In present study, the prevalence of positive pregnancy after IUI procedure was 14.7%. The total pregnancy rate per cycle was 10.6%. Among prognostic factors total motile sperm count, semen preparation technique and first AIH cycle showed positive correlation with the outcome.Conclusions: According to the results of the current study, intrauterine insemination (IUI) can provide many infertile couples with an opportunity of parenting. Before beginning this type of therapy, it is crucial to make the right selection of cases and conduct a thorough assessment of the couples.
RESUMEN
Significant differences were observed among thirty seven genotypes for all the traits studied. High genetic coefficient of variation was recorded for days to 50 per cent flowering. High heritability of 97.33 per cent was observed for pod yield per plant. High heritability and high genetic advance as percent of mean was recorded for plant height, haulms yield per plant, pod yield per plant and kernel yield per plant. These characters could be further improved through single plant selection. Moderate heritability and high Genetic advance as per cent of mean was observed for number of primary branches per plant, number of secondary branches per plant, number of mature pods per plant and 100 pod weight indicating the importance of both additive and non additive gene action in the inheritance of these characters.
RESUMEN
This study is aimed to evaluate the efficacy and safety of montelukast, as monotherapy, in the treatment of chronic stable bronchial asthma in adults. This was a multicentre, open label, non-comparative, prospective, 4-week study. Eligible patients discontinued all anti-inflammatory medication (steroids, chromoglycate sodium) 2 weeks prior to starting therapy with montelukast (10 mg daily). The primary efficacy criteria were improvements in forced expiratory volume in one second (FEV1), peak exploratory flow rate (PEFR) after 4 weeks of therapy. Secondary efficacy criteria were improvement in the patients' symptoms (assessed on an ordinal scale), decrease in discomfort levels (scored on a scale of 0-100), change in peripheral eosinophil counts, decrease in total daily dose of inhaled beta2 agonist (salbutamol). A total of 148 patients, mean age (+/- SD) 40.21 +/- 13.70 years, were enrolled into the study. At the end of the study there were significant improvements in FEV1 and PEFR (29% and 28% increase respectively from baseline values, p<0.000001). The mean total daily dose of inhaled salbutamol decreased significantly from prestudy values of 461 +/- 332 microg/day to 161 +/- 207 microg/day (p<0.000001). The mean eosinophil counts fell from 5.80 +/- 4.90% (+/- SD) to 4.84 +/- 4.42% (+/- SD) (p=0.02). Symptom scores improved significantly as did subjective assessment of discomfort. A total of 29 (19.6%) adverse events were reported, all of which were of mild to moderate intensity. Monotherapy with montelukast significantly improved parameters of asthma control. It was well tolerated with no reports of serious or severe adverse events.