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The Korean Journal of Physiology and Pharmacology ; : 149-154, 2007.
Artículo en Inglés | WPRIM | ID: wpr-728473

RESUMEN

Kainic acid (KA) causes neurodegeneration, but no consensus has been reached concerning its mechanism. Nitric oxide may be a regulator of the mechanism. We identified differentially expressed genes in the hippocampus of mice treated with kainic acid, together with or without L-NAME, a nonselective nitric oxide synthase inhibitor, using a new differential display PCR method based on annealing control primers. Eight genes were identified, including clathrin light polypeptide, TATA element modulatory factor 1, neurexin III, ND4, ATPase, H+ transporting, V1 subunit E isoform 1, and N-myc downstream regulated gene 2. Although the functions of these genes and their products remain to be determined, their identification provides insight into the molecular mechanism(s) involved in KA-induced neuronal cell death in the hippocampal CA3 area.


Asunto(s)
Animales , Ratones , Muerte Celular , Clatrina , Consenso , Hipocampo , Ácido Kaínico , Modelos Animales , Neuronas , NG-Nitroarginina Metil Éster , Óxido Nítrico Sintasa , Óxido Nítrico , Reacción en Cadena de la Polimerasa , ATPasas de Translocación de Protón
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