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Mem. Inst. Oswaldo Cruz ; 85(3): 329-38, jul.-set. 1990. tab
Artículo en Inglés | LILACS | ID: lil-93596

RESUMEN

Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage


Asunto(s)
Vacuna Antipolio Oral/química , Química Farmacéutica , Estabilidad de Medicamentos , Análisis de Regresión , Temperatura
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