RESUMEN
Background: Insulin resistance is manifested by decreased effect of fixed quantity of insulin on glucose metabolism leading to type 2 diabetes mellitus. Visceral obesity has been positively correlated with insulin resistance but its mechanism is not fully defined. Insulin resistance may be the consequence of adipocytokines including visfatin and resistin. This study was designed to observe the effects of thiazolidinediones on lipid profile and levels of adipocytokines [visfatin and resistin] in insulin resistant Sprague Dawley rats
Methods: Ninety Sprague Dawley rats were randomly divided into three groups. Group I served as control. Rats in Group II and III were made insulin resistant diabetics. Group III was treated with rosiglitazone after development of diabetes. Plasma glucose, serum triglycerides [TG], HDL, TG: HDL ratio and serum adipocytokines [visfatin, resistin] levels were analyzed
Results: Body weight and plasma glucose were significantly increased [p<0.05] along with TG: HDL ratio [p<0.05] in group II and group III at the end of 4th week. Serum visfatin and resistin levels also increased significantly [p<0.05] in group II and III at the end of 4th week. Treatment of group III with rosiglitazone led to improvement in insulin resistance with decrease in serum resistin levels [p<0.05] and increase in serum visfatin levels [p<0.05]. Rosiglitazone treatment decreased serum TG level and increased serum HDL level
Conclusions: Deranged lipid profile and increased serum resistin levels indicate insulin resistance and impending hyperglycaemia. Thiazolidinediones augment sensitivity of insulin to restore normoglycemia by improving lipid profile, decreasing serum resistin levels and improving serum visfatin levels
RESUMEN
Background: Insulin resistance is manifested by decreased effect of fixed quantity of insulin on glucose metabolism leading to type 2 diabetes mellitus. Visceral obesity has a positive correlation with insulin resistance but its mechanism is not fully defined. Insulin resistance may be the consequence of adipocytokines including visfatin and resistin. This study was designed to see the effect of thiazolidinediones on visfatin levels in insulin resistant rats
Methods: Ninety Sprague Dawley rats were divided into 3 groups of 30 each. Group I served as control. Rats in Group II and III were made insulin resistant diabetics with high sucrose diet. Group III was treated with thiazolidinediones after development of diabetes. Plasma glucose, serum triglycerides, HDL, TG:HDL ratio and serum visfatin levels were analysed
Results: Body weight and plasma glucose, visfatin levels and TG:HDL ratio were significantly increased [p<0.05] in group II and group III at the end of 4[th] week. Treatment of group III with thiazolidinediones led to improvement in insulin resistance with increase in serum visfatin levels [p<0.05]
Conclusion: Thiazolidinediones augment sensitivity of insulin to restore normoglycaemia by increasing serum visfatin level
RESUMEN
The erythrocyte sedimentation rate [ESR] determination is a commonly performed laboratory test with a time-honored role. However, the usefulness of this test has decreased as new methods of evaluating disease have been developed. The test remains helpful in the specific diagnosis of a few conditions, including temporal arteritis, polymyalgia rheumatica and, possibly, rheumatoid arthritis. It is useful in monitoring these conditions and may predict relapse in patients with Hodgkin's disease. Use of the ESR as a screening test to identify patients who have serious disease is not supported by the literature. Some studies suggest that the test may be useful as a "sickness index" in the elderly or as a screening tool for a few specific infections in certain settings. An extreme elevation of the ESR is strongly associated with serious underlying disease, most often infection, collagen vascular disease or metastatic malignancy. When an increased rate is encountered with no obvious clinical explanation, the physician should repeat the test after an appropriate interval rather than pursue an exhaustive search for occult disease