Effect of soluble insulin administered rectally in rabbits

Soluble insulin [10U/Kg] was given rectally to eight rabbits. Blood glucose level was found to be reduced one hour after insulin administration and the maximum reduction occurred after two hours. The blood glucose level started to recover to normal level after three hours. It is recommended that the rectal route of insulin administration should be further evaluated for its potential use especially in diabetic ketoacidosis and in the maintenance therapy of insulin dependent diabetics