Benign breast lesions clinico-pathological study

A clinicopathological study of 241 patients with benign breast lesions was done in the period from October 1988 to September 1991. Fibrocystic disease constituted the majority [42%], followed by fibroadenoma [32.8%], chronic inflammatory mastitis [14.5%] and duct ectasia [4.6%]

Experimental trials in treatment of chronic Salmonellosis and carrier state with bilharzial infection

In mice, the histopathologic sequences of changes in bilharzial lesions after application of certain antibilharzial drugs are studied. It has become clear that the resulting dense fibrosis may be responsible for the increased portal hypertension observed after treatment. The use of septrin, as antibilharzial drug, has to be reserved only for decompensated cases. In cases with double infections by bilharziasis and S. paratyphi A, carriers and resistant cases, ambilhar and astiban have an antisalmonella action even with low dilution. Astiban and ampicillin are the combination-therapy of choice to mice doublyinfected by bilharziasis and salmonellosis. They rapidly sterilize the liver and spleen of mice as well as the cuticle and caeca of adult worms as detected by culture. Being a safe combination, they produce minimal cytologic changes in the affected organs

relation between schistosomiasis and chronic carrier state in Salmonellosis: an experimental study

Experimentally-infected mice by schistosomal cercariae were also infected by S. paratyphi A to study the inter-relationship during the various stages of development as well as the role of adult worm in producing the carrier state. Cultures of the heartblood, liver, spleen and cuticle of adult worm were done. Immunofluorescent frozen sections of liver, spleen and adult worm were performed. The results showed that whereas schistosomules are not responsible of any prolonged bacteraemia; yet, from the fourth week onwords the ingestion of host-blood leads to prolonged bacteraemia. Specific reaction to S. paratyphi A was detected on the cuticle and caeca of adult worms up to the eight week of Salmonella infection. The liver and spleen also showed non-specific fluorescent reaction. Schistosomiasis leads to prolonged bacteraemia and state of chronic S. paratyphi A carriers by exhausting the R.E.S. of the individual

Characterization of Hodgkin's disease cells in culture [1] the lymphocytes

Lymphocytes derived from the blood as well as the tissue from Hodgkin's patients showed quantitative and qualitative deficit in the T-lymphocytes, pointing to a disturbed immunologic process. The behaviour of lymphocytes in culture - when stimulated by PHA - denotes impaired blastoid transformation suggesting a partial deficit in these lymphocytes. These cells do not share in the neoplastic process as they were always euploid

Characterization of Hodgkin's disease cells in culture [2] Reed strenberg cells and macrophages

The Hodgkin's mononucleated giant cells in culture were proliferating with over-riding, cross over and clumps in suspension, intensified their malignant nature ending in the R.S. non proliferating multinucleated end cells. They were derived from the non-phagocytic supportive cells [reticular cells] as they were non-phagocytic for opsonized dyed yeasts, negative for E resetting. Fc receptors and complement receptors as well as non-specific esterase. The macrophages behaved normally in culture but they proliferated in conditioned medium. They are not the origin of R.S. cell

Soft tissue tumours at Alexandria: a pathologic study

A total of 300 cases of soft tissue tumors were studied using different types of stains. The classification adopted was a rather modified WHO and based on the literature and present findings

effect of cyproheptadine on the hypothalamus and pituitary gland: histopathological histochemical and electron microscopic study

The effect of cyproheptadine [periactin] on the hypothalamus and pituitary gland was studied using four groups of guinea pigs receiving different doses of the drug. Sections were examined histopathologically, histochemically and by electron microscopy

Fiberendoscopy with mucosal biopsy in the diagnosis of gastroduodenal dyspepsia

Multiple biopsies were taken from the body and pyloric antrum of the stomach, duodenum and esophagus, and from any lesion from 50 patients with gastroduodenal dyspepsia an endoscopy was visualized. The biopsies were stained and examined and a comparison between the clinical impression, radiological, endoscopic diagnosis was done. The commonest cause of dyspepsia was gastritis proven by duodenal ulcer and gastric cancer

Cerebellar tumours: behaviour and clinicopathologic study

Eighty cases of cerebellar and fourth ventricular neoplasms were presented [40 medullo-blastomas, 20 astrocytomas, 9 blood vessel tumours, 5 ependymomas, 2 glioblastomas and 4 metastatic tumours]. The tumours were histologically divided into groups with different biologic characteristics. This classification was based on specific morphologic differences which could be demonstrated by relatively simple staining methods without elaborate impregnation. The majority of primary neoplasms in these locations are biologically benign. Complete cure can be obtained in most histologically benign cases provided the tumour is not adherent to vital structures. The use of radiation treatment was recommended in medulloblastoma, ependymoma and solid astrocytomas

Cancer parotid

Malignant tumours of the parotid gland have represented a considerable challenge for surgeons in the last few years. They have a special importance because of their varied morphohistological types, unpredictable clinical behaviour, and their close neighbourhood to the facial nerve. Questions such as the value and type of biopsy, to preserve or to sacrifice the facial nerve, the extent of resection, the indications of radical neck dissection and the benefits of radiotherapy are still awaiting answers. Our experience in the management of 35 cases of primary malignant tumours of the parotid are here discussed and some guidelines for treatment are advised