“Epithelioid hemangioendothelimoma” an unusual lung tumor: A case report.

A 18-year-old Thai woman with preceding asymptomatic skin nodules for 4 years was admitted for the evaluation of progressive dyspnea during the past 4 months. The findings of iron deficiency anemia with diffuse nodular pulmonary infiltrates led to the open lung biopsy with simultaneous skin biopsy. The final pathological diagnosis was epithelioid hemangioendothelioma. Possible primary soft tissue tumor with lung and liver metastasis was postulated from the clinical findings ad investigative results.

Electron microscopical and immunohistochemical studies of liver tissue in thalassaemic patients: Emphasis on iron and hepatitis B virus.

Fine structure and immunohistochemical studies were investigated in 30 thalassaemic patients. They were diagnosed as having beta thalassemis/haemoglobin E in 19 cases, haemoglobin H disease in 7, and beta thalassemia major in 4. Regardless of the type of haemoglobin, lysosomal haemosiderin was present in various degrees in all cases and some were associated with ferritin molecules. The ferritin molecules were found in both cell sap and lysosome, in four forms: paracrystalline arrangement, hexagonal pattern, finger print fashion and unorganized form. By peroxidase-anti peroxidase (PAP) technique for the detection of hepatitis B surface (HBs) and hepatitis B core (HBc) antigens, HBsAg was found in 1 case of beta thalassemia/Hb E. Ferro-acidophilic bodies (FAB) and ferro-acidophilic degeneration (FAD) were also found. FAB and FAD were probably due to iron hepatotoxicity, because no viral particles were found in this study.