RESUMEN
For the cosmetics and pharmaceutical sectors, marine resources are a promising supply of organic substances. Marine organisms have evolved particular metabolites to combat threats to their survival, reproduction, and the easier storage, movement, and turnover of essential biological materials in habitats with extreme conditions like high salinity, low temperature, or intense pressure.Several newly conducted research studies on pigments, such as violacein, astaxanthin, canthaxanthin, zeaxanthin, rubrolone, and carotenoid derivatives of bacteria from marine sources, confirm their effective radical scavenging activity. Carotenoids are tetraterpene, lipophilic bioactive pigments synthesized by archaea, algae, photosynthetic bacteria, and plants. Carotenoids are divided into two categories, oxygenated carotenoids (xanthophylls) having oxygen as a functional group, and hydrocarbon carotenoids (carotene) made of carbon and hydrogen atoms Carotenoids are important because of their functional properties, which include their usage in the food industry as color additives and natural antioxidants, as well as chemotaxonomic markers and pharmaceuticals. The present review aims to describe 1) carotenoids from marine bacteria 2) the antioxidant properties of carotenoids 3) the Exposure consequences of ultraviolet radiation 4) the protective role of carotenoids. Photoaging, sunburn, and skin cancer are all possible side effects of excessive UV exposure. Carotenoids have potential use in the pharmaceuticals and cosmetic industry as anti-aging, photoprotective, skin-whitening, anticancer, and immunity boosters because of their antioxidant and UV protection properties.
RESUMEN
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease in older adults. The increasing prevalence and disease burden in older adults comes with added challenges of coexisting disease condition. Frailty is an important geriatric syndrome associated with worse clinical outcomes in older adults. COPD and frailty share many common and interrelated risk factors, the presence of one condition worsening the course of other and vice versa. It is important to understand their relation, which can help in management. The continued and supervised pulmonary rehabilitation program has a vital role in the management of COPD and frail patients, providing a better quality of life.
RESUMEN
Objective: The burden of cardiovascular diseases (CVDs) is highest among the older adults, who are often carriers of various geriatric syndromes. Studies evaluating CVDs among the old adults in the low? and middle?income countries are limited. This study was conducted to assess the frequency of CVDs and their risk factors among the older population and their association with geriatric syndromes. Subjects and Methods: In this cross?sectional study, 200 health?care seeking adults aged ?75 years were subjected to routine comprehensive geriatric assessment (assessment for functionality, cognition, depression, frailty, and various geriatric syndromes) and a detailed cardiovascular evaluation using electrocardiography, chest X?ray, echocardiogram, HbA1c level, fasting lipid profile, thyroid function test, serum homocysteine level, and serum NT?pro?BNP. Results: The overall frequency of CVDs in this study was 76%. Polypharmacy, multi-morbidity, cognitive impairment, depression, frailty, and impairment of basic and instrumental activities of daily living were present in 50.5%, 91.5%, 6.5%, 10%, 30.5%, 24.5%, and 55% individuals, respectively. CVDs were significantly associated with increased risk of geriatric syndromes (multi?morbidity [odds ratio (OR) 3.61, confidence interval (CI) 1.13 – 11.54, P = 0.030], polypharmacy [OR 5.46, CI 2.23 – 13.34, P = 0.001] and frailty [OR 3.29, CI 1.01 – 10.64, P = 0.047]). Conclusion: The prevalence of CVDs and their risk factors among the older population was high and significantly associated with increased risk of geriatric syndromes. These observations further strengthen the need for routine geriatric assessment and integrated management of geriatric syndromes in older patients with CVDs.
RESUMEN
Background: Falls are one of the leading causes of disability among older people. The risk factors of falls widely vary among the older populations, including the different stages of cognitive impairment. We aim to identify the risk factors for falls among cognitively impaired older adults. Materials and Methods: In a cross-sectional study, older adults attending the memory clinic were screened for falls and their risk factors. A total of 112 subjects who satisfied the inclusion criteria and provided informed consent were subjected to a semi?structured interview and comprehensive geriatric assessment. Cognitive impairment was graded by the Clinical Dementia Rating (CDR). Subjects were divided into fallers and nonfallers. A multivariable logistic regression analysis was done to identify the independent risk factors of falls. Results: The prevalence of falls was 39.28% in the study population. Gender (adjusted odds ratio [aOR] [95% confidence interval (CI)]: 2.21 [0.690�117]), body mass index (aOR [95% CI]: 0.89 [0.773�028]), socioeconomic status (middle-class aOR [95% CI]: 0.34 [0.077�526], lower-class aOR [95% CI]: 2.44 [0.349�.160]), multimorbidity (aOR [95% CI]: 19.39 [1.043�0.373]), depression (mild aOR [95% CI]: 2.90 [0.896� 9.429] and moderate aOR [95% CI]: 4.77 [0.967�.597]), and impairment in hobbies and home (aOR [95% CI]: 24.78 [6.251�.294]) part of CDR were the independent predictors of falls. Conclusion: Older adults with cognitive impairment are at high risk of falling with definitive risk factors. Regular screening will help to identify older adults at risk of falls and enable fall prevention to reduce morbidity and dependency.