Effect of Estrogen to Antioxidant Enzymes in Rat Erythrocyte / 대한산부인과학회잡지

OBJECTIVE: To observe whether any relationship exists between the consentration of plasma estradiol (E2) and the plasma consentration of malondialdehyde (MDA) or whether a relationship exists between the consentration of plasma E2 and the activity of erythrocyte enzymes, superoxide dismutase (SOD) and catalase, in ovariectomized female rats. METHODS: We used 40 ovariectomized Sprague-Dewley rats randomly assigned to four groups. The first group (group A) was allowed to evolve freely with no estrogen supply. A gel containing 17beta-estradiol was administered transdermally to the other three groups at dose of 5 micro gram/day (group B), 10 micro gram/day (group C) and 15 micro gram/day (group D). After 2 weeks of recovery date from operation and 4 weeks of estrogen treatment, blood samples were obtained from the four groups. The concentrations of plasma E2 and MDA and the concentrations of erythrocyte catalase and SOD were determined. RESULTS: There were significant correlations between the plama E2 concentrations and the concentrations of erythrocytes catalase and SOD in the group C, D. Whereas catalase and SOD activities in erythrocytes was decreased in estrogen replacement group. Any relationship wasn't found between the E2 concentrations and the plasma MDA levels in all groups. CONCLUSION: Thiese result suggested that the catalase and SOD in erythrocytes is related the plasma E2 concentration. This model may explain the contradictory findings presented by estrogens with respect to their pro-or antioxidant action. The further study will be needed to evaluate the effect of estrogen induced plasma lipid peroxidation.

Effect of Estrogen to Antioxidant Enzymes in Rat Erythrocyte / 대한산부인과학회잡지

OBJECTIVE: To observe whether any relationship exists between the consentration of plasma estradiol (E2) and the plasma consentration of malondialdehyde (MDA) or whether a relationship exists between the consentration of plasma E2 and the activity of erythrocyte enzymes, superoxide dismutase (SOD) and catalase, in ovariectomized female rats. METHODS: We used 40 ovariectomized Sprague-Dewley rats randomly assigned to four groups. The first group (group A) was allowed to evolve freely with no estrogen supply. A gel containing 17beta-estradiol was administered transdermally to the other three groups at dose of 5 micro gram/day (group B), 10 micro gram/day (group C) and 15 micro gram/day (group D). After 2 weeks of recovery date from operation and 4 weeks of estrogen treatment, blood samples were obtained from the four groups. The concentrations of plasma E2 and MDA and the concentrations of erythrocyte catalase and SOD were determined. RESULTS: There were significant correlations between the plama E2 concentrations and the concentrations of erythrocytes catalase and SOD in the group C, D. Whereas catalase and SOD activities in erythrocytes was decreased in estrogen replacement group. Any relationship wasn't found between the E2 concentrations and the plasma MDA levels in all groups. CONCLUSION: Thiese result suggested that the catalase and SOD in erythrocytes is related the plasma E2 concentration. This model may explain the contradictory findings presented by estrogens with respect to their pro-or antioxidant action. The further study will be needed to evaluate the effect of estrogen induced plasma lipid peroxidation.

The Clinical study of Pelviscopic Surgery / 대한산부인과학회잡지

OBJECTIVE: Pelviscopic surgery has been used in the treatment of some gynecologic disease. And now, it is applied in almost all cases of gynecologic disease. This study is performed to evaluate the clinical advantages of pelviscopic surgery. Mehtods: From March, 1997 to February 1999, total 310 cases were received laparoscopic surgery on dept. OBGY of Seonam University hospital and Chosun University hospital. We reviewed the chart and analyzed these cases about age, parity, clinical indication, operation type, duration of hospitalization, operation time and complication. RESULTS: The results of this study were summarized as follows : 1. The mean age of patients was 32.1 years old with ranges between 15 and 54 years old. 2. The mean parity of the patients was 1.33. 3. The common indications were ectopic pregnancy (33.5%), ovarian cyst (28.4%) and uterine myoma (16.5%). 4. The frequent types of surgery were salpingectomy (23.2%), adnexectomy (22.6%) and laparoscopy assisted vaginal hysterectomy (LAVH) (13.9%). 5. The operation time was variable according to the types of operation and difficulty. 6. The mean duration of hospitalization was 4.17 days. 7. The most frequent complication was hemorrhage at the trocar site. CONCLUSION: Pelviscopic surgery is useful and recommended for the treatment of gynecologic disease, because this is safe and has many advantages. So, we expect the number and indication of pelviscopic surgery will be increased in future.

A Case of Krukenberg Tumor associated with Ovarian Dermoid Cyst / 대한부인종양콜포스코피학회잡지

Krukenberg tumor, which can account for 30-40% of metastatic cancers to the ovaries, arises in the ovarian stroma and is usually metastatic from the gastrointestinal tract, especially from the stomach. The pathognomonic feature is the presence of signet ring cells, which may be arranged in acini or appear as individual cells. We experienced a Krukenberg tumor which was bilateral and associated with left ovarian dermoid cyst. This patient was treated for a primary gastric carcinoma(Stage II) about 3 years ago. After bilateral salpingoophorectomy, she received adjuvant chemotherapy. But, she died about fow months after operation.