Endothelial damage potentiated by smoking in male Subjects with schistosoma mansoni

The cummulative effect of smoke inhalation inducing free radical generation and potentiating endothelial damage influencing liver and kidney function with alterations of lipid metabolism accelerating lipid peroxidation products and atherogenesis was evaluated in male smokers categorised into light and heavy smokers. The impact of schistosomal affection on the overall process of change monitored in smokers [age range 25 - 40] expressed more profound out come, which would influence furthermore the magnitude of hepatic insult and sequence of events in such cases

Coagulopathy: influence of Schistosoma mansoni and Hbs Ag altered equilibria in post-partum preeclamptic states

The anticoagulants, protein C [PC], protein S [PS] and thrombin-antithrombin complex [TAT] were assessed in four selected groups involving non-pregnant cases [Group I[A]IV[A]] [G I[A]; were considered as controls, G II[A]: with active schistosomiasis, G III[A]: with hepatitis B surface antigen [Hbs Ag] carrier inactive state and G IV[A]: with S. mansoni and Hbs Ag carrier inactive state], and allied cases immediately after delivery [Group I[B]-IV[B]]. A similar category of selected groups were assessed for those suffering from preeclampsia [PE] prior to delivery [Group I[C]-IV[C]]. The groups involved normal control group [G I], a group with schistosoma mansoni [G II], a group that were inactive Hbs Ag carrier [G III] and a group with schistosoma and inactive Hbs Ag carrier state [G IV]. Reduced PC, PS vs elevated TAT [G IV[A] > G II[A] > G III[A] > G I[A]] were presented in non-pregnant states. Assessed values immediately after delivery showed greater-magnitude of change in PE than those with normotensive pregnancies with significantly higher TAT. A relative decrease of PC and PS levels [G Iv[C] > G lic > G III[C] > G I[C]] compared to [G IV[B] > G II[B] > G III[B] > G I[B]] was apparent. Significant decrease of PC and PS were evident only in G Iv[C]. In conclusion, preeclamptic schistosomal cases with inactive Hbs Ag carrier state presented greater risk of thrombotic complications owing to inadequate complementary compensatory mechanism between PC and antithrombin III [AT III]