RESUMEN
Objectives: E-cadherin is a transmembrane glycoprotein, which is responsible for cell adhesion and its expression decreases in dysplastic lesions. This study aimed to assess the expression of this marker in oral lichen planus [OLP] with and without dysplasia to assess its potential for use as a predictor of malignant transformation
Methods: this descriptive, cross-sectional study was conducted on 44 OLP specimens using immunohistochemistry [IHC] by streptavidin-biotin technique. For this purpose, E-cadherin antibody was used and the intensity score [IS], proportional score [PS] and total score [TS] were calculated. Data were analyzed using SPSS version 21. The relationship between the intensity of expression of E-cadherin and dysplastic changes was assessed using the Mann Whitney U test. P<0.05 was considered significant
Results: the TS of E-cadherin expression was 3 to 6 and 3 in the superficial and deep layers of 100% of specimens with dysplasia, respectively. The TS of E-cadherin expression was 3 to 6 in the superficial layer of 82.5% of specimens and 3 in deep layers of 81.2% of specimens without dysplasia. According to the Mann Whitney U test, the expression of E-cadherin in the superficial [P=0.90] and deep [P=0.35] layers was not significantly different between the two groups of OLP with and without dysplasia
Conclusion: no significant difference was found in the expression of E-cadherin in OLP specimens with and without dysplasia. It may be concluded that in contrast to other preneoplastic lesions, dysplastic changes of OLP do not follow other malignant transformation patterns in the oral mucosa
RESUMEN
Objectives: periapical Granulomas [PGs] and Radicular Cysts [RCs], as the most common odontogenic lesions have yet unclear pathogenesis. This study was aimed to compare PCNA and Ki-67 expression in PGs and RCs and evaluate their possible relationship with two lesions
Methods: in this cross-sectional descriptive study, twenty PGs and twenty RCs were evaluated immunohistochemically using an anti-PCNA and anti-Ki-67 polyclonal antibodies. PCNA[+] and Ki-67[+]cells were counted in connective tissue wall and epithelial lining [in RCs]. Statistical analysis was performed by using Mann-Whitney U test and Spearman's rank correlation coefficient
Results: in PGs, percentage of PCNA and Ki-67 expression were found 70% and 30%, respectively; In RCs, PCNA and Ki-67 expression were observed 90% and 55%, respectively. Additionally, in RCS, Immunoexpression of PCNA [85%] and Ki-67 [60%] were detected at epithelial lining area. The positive immunoexpression of PCNA in RCs was greater than PGs [p<0.05]
Conclusion: immunoexpression of PCNA and Ki-67 were detected in both lesions which may be mentioned as valuable markers for the prediction of biologic behavior of PGs and RCs
RESUMEN
Objectives: the purpose of this study was to determine the frequency of all odontogenic cysts [OCs] along with age range, gender distribution, and the site of involvement over a 10-year period [March 2001 to March 2011] and to compare these data with findings from other surveys
Methods: the archives of departments of oral and maxillofacial pathology from Shahid Beheshti and Tehran University of Medical Sciences were retrieved and analyzed for demographic data such as age, gender, location and histopathological diagnosis of OCs
Results: of the 8,563 biopsy samples that were received, 1,518 [17.7%] were diagnosed as OCs. Radicular cyst was the most common diagnosis [33.2%], followed by dentigerous cysts [24.1%], and odontogenic keratocysts [18.6%]. OC occurred 59.3%, 40.6% in male and female respectively. Mandibular involvement was 62.4% while in maxilla was 37.6%
Conclusion: our study provided demographic data on a large series in Iran, a Southwest Asian country. In our study, radicular cysts, the most common OC, had a lower frequency compared to that reported in most other studies. On the other hand, calcifying OCs seem to be more prevalent in the Iranian population compared to other populations male to female to female ratio was 1.45:1
RESUMEN
Objective: The Ortho keratinized Odontogenic Cyst [OOC] is a rare lesion originates from dental lamina and clinically, it may be mistaken for many other odontogenic cysts and Tumors. Microscopically, It should be distinguished from KCOT because of differences in biologic behavior and histologic features
Case: An interesting case of OOC arising in the edentulous mandibular right first premolar region of a 55-year-old woman is reported. Under the initial clinical diagnosis of a residual cyst, the excisional biopsy was performed. Because of detection of an orthokeratinized epithelium lining, a definite diagnosis of OOC was made
Conclusion: Microscopic examination is crucial for making the correct diagnosis of such lesions, therefore establishing patients' prognosis accurately