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Yonsei Medical Journal ; : 1158-1167, 2013.
Artículo en Inglés | WPRIM | ID: wpr-198360

RESUMEN

PURPOSE: NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic factors for cancer development and progression. The purpose of this study is to investigate the relationship between NQO1/NQO2 genotype and clinico-pathological features of papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS: Genomic DNA was isolated from 243 patients; and clinical data were retrospectively analyzed. NQO1*2 and tri-allelic polymorphism of NQO2 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: PTMC with NQO1*2 frequently exhibited extra-thyroidal extension as compared to PTMC with wild-type NQO1 (p=0.039). There was a significant relationship between I29/I29 homozygosity of NQO2 and lymph node metastasis (p=0.042). Multivariate analysis showed that the I29/I29 genotype was associated with an increased risk of lymph node metastasis (OR, 2.24; 95% CI, 1.10-4.56; p=0.026). CONCLUSION: NQO1*2 and I29 allele of the NQO2 are associated with aggressive clinical phenotypes of PTMC, and the I29 allele represents a putative prognostic marker for PTMC.


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Carcinoma Papilar/genética , Análisis Mutacional de ADN , Predisposición Genética a la Enfermedad , Inmunohistoquímica , Análisis Multivariante , Mutagénesis Insercional , Mutación Missense , NAD(P)H Deshidrogenasa (Quinona)/química , Fenotipo , Polimorfismo Genético , Pronóstico , Regiones Promotoras Genéticas , Estudios Retrospectivos , Análisis de Secuencia de Proteína , Eliminación de Secuencia , Neoplasias de la Tiroides/genética
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