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1.
Southeast Asian J Trop Med Public Health ; 1992 ; 23 Suppl 2(): 110-5
Artículo en Inglés | IMSEAR | ID: sea-35730

RESUMEN

Liver tissues from 17 patients with advanced stages of beta-thal/Hb E disease were examined by light and electron microscopy, with emphasis on cellular damage due to excess iron overload. Various histochemical stains were performed to grade degrees of iron deposition and fibrosis, and to demonstrate hepatitis B surface antigen, in Kupffer cells as well as macrophages. The results of light and electron microscopic studies were correlated. There was a variation in the distribution of hepatic iron and the severity of fibrosis. In most of the cases ballooning degeneration of the hepatocytes, increase in number of lysosomes, hemosiderin and ferritin in hepatocytes as well as in the sinusoidal lining cells were found. The ferro-acidophilic body, representing another important form of hepatocellular necrosis also occurred. So far no precise mechanisms can be concluded.


Asunto(s)
Adolescente , Adulto , Biopsia , Femenino , Ferritinas/química , Hemoglobina E , Hemoglobinopatías/complicaciones , Hemosiderosis/epidemiología , Antígenos de Superficie de la Hepatitis B/química , Hospitales Universitarios , Humanos , Hiperplasia , Hipertrofia , Macrófagos del Hígado/patología , Cirrosis Hepática/epidemiología , Lisosomas/química , Macrófagos/patología , Masculino , Microscopía Electrónica , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Tailandia/epidemiología , Talasemia beta/complicaciones
2.
Artículo en Inglés | IMSEAR | ID: sea-41262

RESUMEN

Glycogen storage disease type IV is rare. The disease is characterized by widespread storage of a polysaccharide similar to amylopectin. An autopsy case of a 6-year-old Thai boy with cirrhosis and deposits in the liver, heart, muscle and central nervous system was described along with histochemical and electron microscopic findings.


Asunto(s)
Niño , Enfermedad del Almacenamiento de Glucógeno/patología , Enfermedad del Almacenamiento de Glucógeno Tipo IV/patología , Humanos , Hígado/patología , Masculino , Microscopía Electrónica , Músculos/patología , Miocardio/patología , Tailandia
10.
Southeast Asian J Trop Med Public Health ; 1978 Dec; 9(4): 558-67
Artículo en Inglés | IMSEAR | ID: sea-32090

RESUMEN

An electron microscopic study was carried out on eleven surgical liver biopsy specimens obtained from patients with cholangiocarcinoma associated with opisthorchiasis. The tumor cells of histologically well differentiated cholangiocarcinoma had few cytoplasmic organelles. They contained relatively large nuclei, abundant free ribosomes and numerous groups of fine fibrils. Each cell was surrounded by a basement membrane. Numerous long microvilli were seen projecting into the glandular lumen. The moderately differentiated cholangiocarcinomatous cells exhibited increased organelle content, marked variation in the shape of the nuclei with deep cytoplasmic invagination into the nuclear membrane; there were small intranuclear pseudoinclusions, and shorter microvilli. The tumor cells showed intracellular microvillus-lined spaces, abundant free ribosomes, many fine fibrils and their surrounding basement membranes were incomplete. The ultrastructure of the poorly differentiated cholangiocarcinoma was similar to that of the moderately differentiated tumor, except for fewer microvilli, abundant cytoplasmic organelles, and ill-defined or absent basement membrane.


Asunto(s)
Adenoma de los Conductos Biliares/complicaciones , Adulto , Anciano , Neoplasias de los Conductos Biliares/complicaciones , Conductos Biliares Intrahepáticos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Opistorquiasis/complicaciones
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