A Case-Control Study on dietary Factors of Colorectal Adenomatous Polyps by Sites / 한국역학회지

Colorectal adenomas are benign neoplasm in the large bowel that are thought to be precursors lesion to colorectal cancer. So, studying adenomatous polyps instead of cancer might allow one to measure the diet of relatively asymptomatic subjects closer to the time of the initial neoplastic process. Some dietary factor, or set of factors, apparently plays an impotant role in the etiology of colorectal adenomatous polyps. The difference of the possible association of colorectal adenomatous polyps with dietary risk factors by anatomic subsite and gender was investigated in this case-control study. Between July 1994 and April 1998, 314 cases of patients with pathologically confirmed incident colorectal adenomatous polyps and 88 control subjects were collected from Our Lady of Mercy Hospital, The Catholic University. After colonoscopy, infor-mation on exposure was obtained by the interviewers. Also, subjects were interviewed using the semiquantitative food frequency questionnaire, and average daily nutrient intakes were calculated. Site- and gender-specific odds ratio relative to the lowest tertile of intake for each nutrient were determined using unconditional logistic regression after adjusting for a number of potential confounders. In females, significant odds ratio were found for b-carotene(0.31, 95% CI, 0.10~0.95), vitamin C(0.11, 95% CI, 0.02~0.61), vitamin-E(0.11, 95% CI, 0.02~0.78) in right colon but only the odds ratio of vitamin E(0.17, 95% CI, 0.03~0.90) was statistically significant in left colon. Among food groups, the odds ratio of green yellow vegetables was significant(OR=0.21, 95% CI, 0.05~0.96) in right colon. In males, almost all the above dietary factors were statistically not significant. In males, cigarette smoking appears to be a signigicant risk factor(OR=8.86, 95% CI, 1.10~71.5) in left colon, it was statistically not signigicant(OR=1.63, 95% CI, 0.42~4.76) in the right colon. Findings fron this study show that many associations of the nutrients with colorectal adenomatous polyps risk are different by anatomic subsite and gender and support the hypothesis that high intake of antioxidant vitamins and green yellow vagetables decreases the risk of polyps.

Clinical Observation on Bladder Rupture / 대한비뇨기과학회지

A clinical observation was made on 26 cases of bladder rupture (16 patient had intraperitoneal rupture and 10 patient had extraperitoneal rupture) in the Department of Urology, Catholic Medical College from Jan. 1972 to Feb. 1981. The following results were obtained: 1. The bladder rupture was 26 cases (12.0%) of 217 urogenital injuries. 2. The 26 patient comprised 20 males and 6 female cases. Nine patients were belong to the age group of 31 to 40 years old, 8 Cases were 41 to 50 years old and 5 cases were 21 to 30 years old. 3. Traffic accidents were responsible for the injury in 10 patients, direct blow in 6 patients, industrial accidents in 5 patients and spontaneous bladder ruptures were seen in 2 patients. 4. The major clinical manifestations of bladder rupture were hematuria (20 patients, 76.9%) and abdominal pain and distension(12 patients, 46.2%). 5. Of the 26 patients, 15 had associated fractured pelvis, 7 had fractured extremity, 6 had urethral rupture, 3 had intestinal injury and 3 had skull fracture. 6. Diagnosis was made by retrograde cystography, laparatomy and cystoscopy. Twenty cases (76.9%) was diagnosed by retrograde cystography. 7. Four patients with intraperitoneal rupture and 6 patients with extraperitoneal rupture were treated by operative repair Of the defect with suprapubic cystostomy and drainage of the perivesical space. Twelve patients with intraperitoneal rupture and 2 patients with extraperitoneal rupture were treated by operative repair of the defect with indwelling urethral catheter and drainage of the perivesical space. The remaining 2 patients of extraperitoneal bladder rupture were treated by indwelling urethral catheter for7 to 10 days. 8. There was a 7.7% mortality rate.