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China Pharmacy ; (12): 956-962, 2019.
Artículo en Chino | WPRIM | ID: wpr-817022

RESUMEN

OBJECTIVE: To evaluate clinical efficacy of Guanxin shutong capsule (GSC) in the adjuvant treatment of unstable angina pectoris (UAP), and to provide evidence-based reference for clinical treatment of UAP. METHODS: Retrieved from PubMed, Embase, Cochrane library, CBM, CNKI, VIP and Wanfang database, randomized controlled trials(RCTs)about routine treatment (trial group) of GSC combined with western medicine versus western medicine routine treatment (control group) in the treatment of UAP were collected during database establishment to Oct. 11th , 2018. After data extraction of included literatures and quality evaluation with Cochrane bias risk evaluation tool 5.1.0, Meta-analysis of total response rate of angina pectoris, total response rate of ECG, blood lipid levels (TC, HDL-C, LDL-C, TG), the level of hs-CRP were performed by using Rev Man 5.2 statistical software. TSA 0.9 software was used for trial sequential analysis (TSA) of the total response rate of angina pectoris and response rate of ECG. RESULTS: A total of 11 RCTs were included, involving 946 patients. Results of Meta-analysis showed that total response rate of angina pectoris [RR=1.24,95%CI(1.16,1.32),P<0.001] and total response rate of ECG [RR=1.22,95%CI(1.11,1.34),P<0.001] in trial group were significantly higher than control group. The improvement of TC [SMD=-1.55,95%CI(-1.81,-1.29),P<0.001], TG [SMD=-0.84,95%CI(-1.08,-0.60),P<0.001], HDL-C [SMD=0.15,95%CI(0.06,0.25),P=0.001], LDL-C [SMD=-0.62,95%CI(-0.76,-0.48),P<0.001] and hs-CRP [SMD=-2.54,95%CI(-3.88,-1.88),P<0.001] in trial group were better than control group. TSA analysis showed that the evidence of Meta-analysis was reliable. CONCLUSIONS: GSC combined with western medicine routine treatment can improve total response rate of angina pectoris, total response rate of ECG, blood lipid and hs-CRP level of UAP patients.

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