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Familial hypomagnesemia with secondary hypocalcemia (FHSH) is a rare autosomal recessive disorder that is manifested as severe hypomagnesemia and moderate to severe hypocalcemia. Affected children present with refractory seizures in infancy. It results from mutations in the gene encoding transient receptor potential cation channel member 6 (TRPM6) on chromosome 9q22. The primary defect is impaired intestinal absorption of magnesium with secondary defect in the renal conservation of magnesium. We report two infants who presented with refractory seizures beginning in the first three months of life, the clinical phenotype of both these children was normal. Both were diagnosed to have hypocalcemic seizures. The children were managed with intravenous calcium and magnesium during their hospital stay, however were discharged on calcium supplementation alone. As they continued to have seizures inspite of good compliance to medications and in view of persistently low magnesium levels, hypomagnesemia as a cause of seizures was considered. Genetic evaluation revealed variants in the TRPM6 gene in both the cases The seizures were brought under control once the magnesium levels were normalized. A possibility of hypomagnesemia with secondary hypocalcemia should be thought of in any case of refractory hypocalcemia and inappropriately low levels of parathyroid hormone (PTH) The purpose of this series is to highlight the importance of systematically working up children with inherited hypomagnesemia.
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Objective: The present study was carried out with three varieties (green, pink, and sweet) of Carissa carandas fruit extract for the identification of phytochemical constituents in C. carandas fruit extracts using Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GCMS)Methods: LC MS/MS and GCMS analysis were adopted to study three varieties of C. carandas fruit, namely green, pink, and sweet, using different solvent extractions such as ethanol, methanol, and aqueous.Results: High levels of phenolic acids and flavonoids in the green variety were beneficial for anti-diabetic activity due to their antioxidant properties. Among the three varieties of tested samples, the maximum concentration was observed in the ethanol extract of the green varieties (2.485 mg/g FW) compared to the ethanol extract of the pink (1.564 mg/g FW) and sweet (1.285 mg/g) varieties, respectively. Ethanol extract of the green variety has a high level of anthocyanin, which increases tolerance to disease. The separation and identification of fatty acids in C. carandas fruit were determined through analysis. The sweet C. carandas variety recorded the highest concentration of fatty acids (147.2 mg/100g FW) compared to the pink and green varieties (94.9 mg/100 g FW) and (72.79 mg/100 g FW), respectively, and could successfully identify the number of phytonutrients that have health benefits. Further work is being carried out, which may lead to the development of herbal medicine.Conclusion: The present study concludes that phytochemicals present in C. carandas fruit, extracted by LC-MS and GC MS analysis, contain antioxidant and anti-diabetic effects.
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Background: Pregnancy related acute renal failure is still common in developing countries. This study is aimed to evaluate the etiological factors responsible for ARF in pregnancy, and, maternal and fetal outcome of this condition. It contributes upto 20-22% of the referrals to higher centers and is associated with high risk of maternal mortality (9 to 55%) in developing countries.Methods: This is a prospective study carried out at M. R. medical college and Basaweshwara teaching hospital, Kalaburagi (Gulbarga), for one year from January 2017 to December 2017.Results: A total of 38 patients were hospitalised with renal failure in pregnancy. Majority of the patients (73.68%) were multigravida. Eclampsia (42.10%) and severe post-partum hemorrhage (21.05%) were the most common causes of acute renal failure in late third trimester and in post-partum period. Edema (65.78%) and oliguria (50%) were the most common presenting complaints. Most cases (73.68%) responded to diuretics and IV fluids. 21.05% required dialysis, 39.47% needed ICU admissions. Maternal mortality amounted to 13.15%. Fetal IUGR (18.42%), preterm delivery (13.15%), fetal distress (10.52%), NICU admissions (15.78%), and still births (7.89%) were noted.Conclusions: Pregnancy related acute renal failure is still high in developing countries. Good antenatal care, correction of anaemia, early diagnosis and management of pre-eclampsia, good transport facilities to shift to tertiary care centers are essential requirements to reduce maternal and fetal mortality and morbidity due to acute renal failure in pregnancy.
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Background: Urinary tract infection (UTI) during pregnancy is very common in developing countries like India. UTI is caused by the growth of micro-organisms in the urinary tract. This study aims to determine the incidence of UTI in whole pregnancy and its adverse effects on mother and fetus.Methods: This is a prospective study conducted in outpatient department of ESIC medical college for one year from January 2017 to December 2017. A total of 182 pregnant women attending OBG OPD for ANC check-up without any medical disorders or previous adverse pregnancy outcomes of 18-35 years of age were included in the study. Urine routine and urine culture sensitivity were done for all.Results: Out of 182 pregnant women tested for UTI, the incidence of UTI in pregnancy was found to be 19%. Asymptomatic UTI was noted in 65% patients with UTI. Primigravida were commonly affected (56%). Highest cases were in 18 to 25 years (63%) age group. 56% cases showed 6-10 pus cells/HPF. Prevalence of UTI was more common in winter seasons. Commonest causative organism was E. coli in 38% cases. Maternal complications like anaemia (26%) and puerperal pyrexia (23%) were observed. Adverse fetal outcomes like preterm birth (35%) and fetal growth restriction (15%) were observed.Conclusions: In this study, the prevalence rate of UTI during pregnancy is high (19%). The physiological changes of pregnancy predispose the women to UTI so does the other factors such as age, sexual activity, hygiene, multiparty, previous history of UTI and socio-economic conditions. All pregnant women should be screened for UTI with a urine routine and urine culture, treated with antibiotics if the culture is positive and then retested for cure. Awareness has to be created about good hygienic practices and adequate hydration among pregnant women.
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Monocropping makes agriculture more susceptible to the adverse effects of climate change. Resilient agriculture systems that can buffer crops against various agricultural vulnerabilities is the need of the hour. In this context, a study was conducted to assess the impact of various rice based cropping systems on soil health.Aims: To study the effect of different rice based cropping systems on soil enzyme activity and organic carbon.Study Design: Randomized block design, Replications – 3.Place and Duration of Study: Integrated Farming System Research Station (IFSRS) of Kerala Agricultural University located at Karamana, Thiruvananthapuram, during kharif, rabi and summer seasons of 2019-2020.Methodology: The experiment consists of eleven cropping systems (T1 : rice - fallow - fallow, T2 : rice - rice - fallow, T3 : rice - daincha - cowpea, T4 : (rice + daincha) - rice - green gram, T5 : rice - cassava - amaranthus, T6 : rice - cassava - cowpea, T7 : rice - para grass - fodder cowpea, T8 : rice - fodder cowpea - fodder maize, T9 : rice - okra - culinary melon, T10 : rice - okra - yard long bean and T11 : rice - rice – amaranthus).Results: Soil organic carbon and enzyme activities were found highest in the cropping system (rice+daincha) – rice – green gram during kharif. During rabi, soil organic carbon and activity of urease and acid phosphatase were highest in rice- daincha- cowpea while dehydrogenase activity was highest in rice- fodder cowpea – fodder maize. During summer, rice- okra – yard long bean, rice- cassava- amaranthus and rice- cassava – cowpea recorded the highest urease, acid phosphatase and dehydrogenase activity, respectively. The organic carbon was highest for the sequence rice – okra –culinary melon. The soil organic carbon and enzyme activities were least in rice- fallow-fallow cropping sequence during all the three cropping seasons.Conclusion: Brown manuring, use of leguminous crops and cover crops in the crop sequence instead of leaving the land fallow and addition of organic sources of nutrition increase the soil organic carbon and enzymatic activity of microbes. The increase in soil organic carbon and activity of enzymes in soil owing to crop rotation of rice with arable crops relies on the crop species which are cultivated.
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Rice production has been significantly hindered by frequent drought events in recent times, directly impacting food security and agricultural sustainability. In the current study, a set of 100 diverse rice accessions from 3K RG panel were evaluated for Epidermal patterning factor 2 (OsEPF2) loci which governs the stomatal density on the matured leaves by preventing excessive stomatal development. This plays an important role in drought tolerance in plants. Hence, this gene was selected for analyzing haplotype variation which revealed 27 SNPs and 59 INDELs. Seven significant non-synonymous SNPs, grouped the one hundred accessions into three haplotype groups with the allelic combination CGATGCG for H1, TTGGAAA for H2 and CGGGGCG for H3. This shows the allelic diversity of the population that can be potentially employed in breeding of rice varieties with improved drought tolerance and water use efficiency by assembling superior haplotype.
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An experiment was conducted to evaluate the performance ginger genotypes under coconut ecosystem at Coconut Research Station, Aliyar Nagar, Tamil Nadu Agricultural University, and Coimbatore during the period from 2017- 18and 2018-19. The experiment was laid out in Randomized Block Design (RBD) with three replications and the treatments included viz., Rejetha, Ashwathy, Maran, Karthika, GCP 49, IISR 1 (GB), Mahima, ACC 578, Athira, ACC 581, Rio de Janeiro, Varadha, Thadimaram and local Gudalore. data were recorded from five randomly selected plants on plant height, shoot diameter, number of shoots, number of leaves, leaf length, leaf breadth, yield per plot and hectare and was analyzed using analysis of variance. Results showed the highest plant height (92.70 cm),shoot diameter (3.27cm), no. of leaves (30), leaf length (27.89 cm) registered in Thadimaram, whereas the highest no. of shoots (8.10), leaf width (3.78 cm), yield per plot (13.64 kg) and yield (24.80t/ha) was recorded in Athira followed by Rejethawhich recorded the highest yield per plot (12.15 kg) and yield (22.09t/ha) during 2017-18.During 2018-19the highest plant height (99.90 cm),shoot diameter (3.60cm), leaf length (29.10 cm) was registered in Thadimaram, whereas the highest no. of shoots (8.30), no. of leaves (36.0), leaf width (3.90 cm), yield per plot (14.20 kg) and yield(25.50 t/ha) was recorded in Athira followed by Rejethawhich recorded the highest yield per plot (12.70kg) and yield (22.80t/ha). Athira and Rejetha genotypes outperformed the other genotypes and could be considered as the most suitable genotypes for cultivation under the coconut ecosystems of Coimbatore district.
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A field experiment was conducted during kharif season of 2021-22 at Agricultural Research Station, Tandur, Vikarabad, Professor Jayashankar Telangana State Agricultural University (PJTSAU) under deep black soils to study the effect of integrated nutrient management on the growth and yield of kharif redgram (Cajanus cajan L.). The experiment was laid out in Randomized block design with 9 treatments in 3 replications. Treatments comprised of T1: Control, T2: 50% RDF (10:25:0 NPK kg ha-1) + 50% FYM (2.5 t ha-1), T3: 75% RDF (15:37.5:0 NPK kg ha-1) + 25% FYM (1.25 t ha-1), T4: 100% RDF (20:50:0 NPK kg ha-1), T5: 50% RDF + FYM @ 5 t ha-1 + Rhizobium (Seed treatment) + PSB (Seed treatment), T6: 75% RDF + FYM @ 5 t ha-1 + Rhizobium (Seed treatment) + PSB (Seed treatment), T7: 100% RDF + FYM @ 5 t ha-1 + Rhizobium (Seed treatment) + PSB (Seed treatment), T8: 100% RDF + Rhizobium (Seed treatment) + PSB (Seed treatment) and T9: FYM @ 5 t ha-1 + Rhizobium (Seed treatment) + PSB (Seed treatment). Among the treatments, application of 100% RDF, FYM @ 5 t ha-1, Rhizobium and PSB recorded significantly higher seed yield (1898 kg ha-1) and stalk yield (6275 kg ha-1).
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Background: The frequency of AITD (autoimmune thyroid disease) and prevalence of thyroid autoantibodies in T1DM (Type 1 diabetes mellitus) patients is much higher than in general paediatric population, varying widely between 3-50% and is often related to age, gender and ethnicity. Although this association has been well established in various populations, very few studies have been done in this regard in South India. The objectives of the study were to study the proportion of abnormal thyroid function and thyroid autoimmunity among T1DM subjects in comparison with general pediatric population and to compare the disease severity among T1DM subjects with and without abnormal thyroid function.Methods: The 45 subjects diagnosed with T1DM (Group 1) and 45 age and gender matched subjects without T1DM (Group 2) were enrolled after applying the inclusion and exclusion criteria. Serum free T3, free T4 and TSH levels were tested for all the subjects in both the groups. In addition, HbA1c levels and Anti TPO antibody titers were tested for subjects with T1DM.Results: Abnormal thyroid function was found in 15.5% of T1DM subjects, in contrast to 2.2% of subjects in the comparison group (p=0.026). The anti-TPO antibody titers were positive in 31.1% of T1DM subjects and among them 42.8% subjects had abnormal thyroid function. T1DM subjects with abnormal thyroid function had significantly higher number of hospitalizations (p<0.05) and total number of ICU admissions (p<0.05)Conclusions: Abnormal thyroid function (predominantly subclinical hypothyroidism) and thyroid autoimmunity was not only more prevalent among T1DM subjects, but was also associated with poor glycemic control. Thus, highlighting the need for screening and a lower threshold for treatment.
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ABSTRACT Introduction: The knowledge of clinicians regarding blood transfusion services may impact patient care and transfusion outcome. The wide variation in transfusion practices among clinicians leads to inappropriate blood product usage and jeopardizes patient safety. Hence, this survey study aimed to assess knowledge, attitude and practice among the residents and interns of safe blood transfusion. Methods: The online survey was based on self-administered questionnaires of three sections: 1. Demography; 2. Knowledge, and; 3. Attitude and Practice. One point was assigned for the correct response of each question in every section. The knowledge score was further categorized into three categories, depending on the points obtained. The participants were also divided into four groups, depending on their experience. The Kruskal-Wallis test was applied to determine the difference of knowledge and practice scores in three designated groups of residents and interns. A p-value of less than 0.05 was considered to be significant. Result: A total of 247 residents and interns participated in this study. Thirteen participants had an incomplete response. Out of 234 participants, Senior Residents (SR), Junior Residents (JR), and interns were 70, 96 and 68 participants, respectively. The knowledge scores of interns were significantly low, as compared to SRs and JRs. Practice scores of interns were also significantly low, compared to the JRs. However, most of the residents and interns (85%) were aware of the pre-transfusion testing. Conclusion: Therefore, the mandatory incorporation of the transfusion medicine subject in the undergraduate curriculum can help the young budding doctors to better implement the patient blood management.
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Background: The menopausal state may predispose the women to the development of metabolic syndrome as its prevalence has been reported to increase after the attainment of menopause. The aim of this study was to determine the prevalence of metabolic syndrome and its components in post-menopausal women and to assess the association between metabolic syndrome and endometrial pathologies in post-menopausal women.Methods: An observational study conducted at gynecology OPD of GSVM Medical College, Kanpur and Total 80 post-menopausal women who had history of at least 1 year cessation of menses.Results: Endometrial pathology was present in 63.2% of patients with metabolic syndrome and in 38.1% of patients without metabolic syndrome. The association between endometrial pathology and metabolic syndrome was found to be statistically significant (p=0.025). The highest incidence was found for fasting glucose (86.8%) followed by blood pressure (81.5%), high triglycerides (81%), low HDL (60.5%), and waist circumference (23.6%). Waist circumference, triglyceride, HDL, diabetes, waist circumference had postulated to be predictors for endometrial pathology.Conclusions: Endometrial cancer is a type of metabolic syndrome-related tumor. Elucidating the specific roles and the possible mechanisms of metabolic syndrome in pathogenesis of endometrial cancer is expected to provide a new target for the early prevention and treatment of endometrial cancer.
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Background: The menopausal state may predispose the women to the development of metabolic syndrome as its prevalence has been reported to increase after the attainment of menopause. The aim of this study was to determine the prevalence of metabolic syndrome and its components in post-menopausal women and to assess the association between metabolic syndrome and endometrial pathologies in post-menopausal women.Methods: An observational study conducted at gynecology OPD of GSVM Medical College, Kanpur and Total 80 post-menopausal women who had history of at least 1 year cessation of menses.Results: Endometrial pathology was present in 63.2% of patients with metabolic syndrome and in 38.1% of patients without metabolic syndrome. The association between endometrial pathology and metabolic syndrome was found to be statistically significant (p=0.025). The highest incidence was found for fasting glucose (86.8%) followed by blood pressure (81.5%), high triglycerides (81%), low HDL (60.5%), and waist circumference (23.6%). Waist circumference, triglyceride, HDL, diabetes, waist circumference had postulated to be predictors for endometrial pathology.Conclusions: Endometrial cancer is a type of metabolic syndrome-related tumor. Elucidating the specific roles and the possible mechanisms of metabolic syndrome in pathogenesis of endometrial cancer is expected to provide a new target for the early prevention and treatment of endometrial cancer.
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The objectives of the programme were to promoting nutritional awareness, education and behavioural change in rural area involving farm women and school children, harnessing traditional knowledge through local recipe to overcome malnutrition and implementing nutrition sensitive agriculture through homestead agriculture and nutri-garden. For this study, All India Coordinated Research Project on Women in Agriculture, MPUAT, Udaipur adopted five villages of Badgaon Panchayat Samiti to make Nutri Smart Villages i.e. Madar, Thoor, Brahmano ki hunder, Feniyon ka guda and Loyra. Regarding nutritional, health and hygiene practices, 57.07 per cent of the respondents followed poor practices. Majority of the rural women were vegetarian. Regarding BMI of respondents, 40.53 per cent women were pre-obese and18.12 per cent were obese. Awareness generation is required regarding importance of good nutrition.
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This synthesis consolidates current research on sustainable agriculture and its pivotal role in enhancing food security, conserving biodiversity, and mitigating climate change. Sourced from a wide array of references, it accentuates exercises such as organic farming, agroforestry, and diversified farming systems as cornerstone approaches, sustainable agriculture. The potential of these practices is also explored, highlighting the carbon sequestration capacity of agroforestry systems, the environmental advantages of organic farming over conventional methods, and the implications of diversified farming systems on food security. However, sustainable agriculture still confronts numerous challenges, especially regarding the environmental repercussions of pesticide use and the barriers hindering the adoption of sustainable farming practices. The substantial role of traditional agricultural practices, which often reflect fundamentals of sustainability and resource preservation, is also underscored. The transformative impact of integrated aquaculture-agriculture systems on small-scale farms in Southern and Southeastern Asia is with Farmer Field School experiences worldwide. Critically, the synthesis acknowledges the daunting task of feeding a burgeoning global population and the environmental ramifications of land utilization. Synthesis concludes by asserting that future research and policy must perpetually focus on these issues, aiming to generate innovative strategies for sustainable agriculture and to bolster the resilience of farming systems in the face of climate change.
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Succinyl CoA 3 oxoacid CoA transferase deficiency (SCOTD) is an autosomal recessive disorder of ketone body utilization which present with recurrent episodes of metabolic acidosis. We have a 23-month old child who presented with 3 episodes of metabolic acidosis. Each time the toxicology profile came positive for ethyl alcohol. We couldn抰 get any history suggestive of poisoning. So we were in a great dilemma and considered the possibility of Munchausen syndrome by proxy and a metabolic cause. Even though the initial genetic result was nonspecific when we reanalyzed the sample for genetic analysis it came positive as Succinyl CoA 3 oxoacid CoA transferase (SCOT) deficiency. The child required intensive care support in all 3 times. We were able to manage the child with supportive measures each time. Now the child is under regular follow up and doing well. SCOTD should be considered in any children presenting as recurrent episodes of metabolic acidosis. The rarity of this disorder will lead to the diagnostic dilemma that we face as like in this case.
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Background: Induction of labor (IOL) is one of the most frequent obstetric procedures require for various obstetrics indications in 13-20% of term. Traditionally success of induction has been determined by Bishop score, but this score is observer based and significant inter observer disagreements have been noted. Ultrasound can help obstetricians in counselling patients before induction of labour and explain the probability of successful induction. So in this study we did ultrasound assessment of foetal head-perineum distance prior to induction of labour as a predictor of successful vaginal delivery.Methods: All eligible women who are planned for induction of labour will undergo ultrasound assessment of foetal head–perineum distance prior to induction of labour. Transvaginal ultrasound will also be performed using ultrasound probe to measure cervical length. After the scans, prevaginal examination will be performed to assess the various components of modified Bishop score (min 0, max 10). If cervix is found unfavourable, induction of labour will be done. If patient did not go into active labour, then induction will be considered unsuccessful) or else oxytocin drip in cases where cervix is found favourable. The patients will be followed up till delivery.Results: Out of 125 patients enrolled for the study, 101 women delivered successfully vaginally and 24 had to undergo caesarean delivery. Of these 24 cases of caesarean delivery, 11 cases were excluded as the operative procedure was performed for indication not related to unsuccessful induction such as occurrence of foetal distress in labour, thick meconium-stained liquor with unfavourable cervix. The final analysis was performed from 114 subjects (101 vaginal births and 13 caesarean births).Conclusions: Transperineal fetal head–perineum distance is less painful as less time consuming and less acceptable by patients compare to Transvaginal measurement of cervical length and painful digital examination for bishop score.
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Gitelman syndrome (GS) is an autosomal-recessive disorder distinguished by hypokalemia, hypomagnesemia, and hypocalciuria. Elderly people and women of childbearing age are highly affected by GC. Not much evidence is known about its effects on maternal and fetal outcomes. GS is caused by mutations in the thiazide-sensitive Na-Cl cotransporter gene. Due to its rarity and lack of knowledge, it is susceptible to misdiagnosis or being overlooked. In our case, the patient suffered from recurrent hypokalemia, hypomagnesemia, hypochloraemia, and hypocalciuria with hypotension. After taking proper medication, the patient recovered slowly, and during counseling, the patient was provided a diet chart by nutritionists to avoid recurrent electrolyte imbalances.
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Aims and objectives: To study the dermatoglyphic patterns in healthy and Type II diabetes mellitus subjects. To study the arches, Ulnar loop, Radial loop and Whorl patterns The present study was conducted i Methods: n the Department of Anatomy, Index Medical College, Indore (M.P.), India. Subjects of the age group 35-65 years was chosen from North Indian Population. Patients and controls were selected randomly from Index Medical College and Hospital, Indore (M.P.) India. The bilateral rolled finger and palm prints of 100 Diabetes Mellitus II patients were compared to 100 controls. Results: Shows that the comparison of right ulnar loop, right whorl, left ulnar loop, left radial loop, and left whorl in male between healthy subjects and type II diabetes mellitus patients, which are statistically significant. (p <0.001). whereas right arch, right radial loop, and left arch is not statistically significant. Fingertip ridge count of right ulnar loop, Conclusions: right radial loop and left ulnar loop, is increased in healthy male subjects as compared to type II diabetes mellitus. While right arch, right whorl, left arch, left radial loop, and left whorl is decreased.
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Introduction: Ameloblastoma is an aggressive, benign, epithelial odontogenic tumor that comprises of 10 % of the odontogenic tumors. Its occurrence is considered a rarity in the younger age group and accounts for approximately 10–15 % of all reported cases of ameloblastoma The aim of this study is to determine the relative frequency ,distribution and histologic type of Ameloblastoma in children and adolescents ? 19 years in a south indian teaching institute. Material and methods: The past 17 year records of the Department of Oral Pathology and Microbiology and dept of pedodontics, Government Dental College Kozhikode, Kerala were retrieved from the archival files between January 2001 and December 2017. Only those cases belonging to pediatric population in the age group 0-19 years were included. Results: Of the total 8967 biopsies received, 991 cases were from pediatric population. Ameloblastoma constituted 23.65% of odontogenic tumors. Mandible was affected more than maxilla. Male predilection was observed in the present study. Conventional ameloblastomama was the major subtype followed by unicystic ameloblastoma. The most common histologic variant of ameloblastoma was found to be Follicular(27.27%) followed by plexiform (13.63%) and acanthomatous ameloblastoma (9.09%). Most of the Ameloblastoma presented as unilocular radiolucency. Conclusion: Ameloblastomas are not uncommon in the south Indian pediatric population. Variations with previous literature seem to be due to ethnic or racial differences, and criteria applied in each study and the lack of infrastructure and facilities to detect asymptomatic lesions.
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Purpose: The research activity in pediatric glaucoma (PG) was qualitatively and quantitatively evaluated using a scientometric approach. Methods: The “Web of Science” database was accessed for primary bibliometric data regarding PG using search terms “pediatric glaucoma,” “paediatric glaucoma,” “congenital glaucoma,” and “childhood glaucoma.” The data was analyzed for total research productivity, citations, and scientific output in terms of journals, countries, institutions, and authors. The results were further characterized for coauthorship links and visualized by VOS viewer software. Also, the top 25 cited articles were reviewed with the above bibliometric characteristics. Results: One thousand two hundred and sixty?nine items were obtained from our search query from 1955 to 2022; these received 15,485 citations, originated from 78 countries. The top?3 contributing countries were the United States of America (n = 369), India (n = 134), and China (n = 127). LV Prasad Eye Institute (n = 58), Duke University (n = 44), and King Khalid Eye Specialist Hospital (n = 42) were the top?3 productive institutes. The top?3 prolific authors were Mandal AK (n = 53), Freedman, SF (n = 36), and Sarfarazi, M (n = 33). Journal wise, “Investigative Ophthalmology” (n = 187), “Journal of Glaucoma” (n = 92), and “Journal of AAPOS” (n = 68) were the journals in which the most articles were published. The top?25 cited documents received 3564 citations and were published between 1977 and 2016. The key areas of interest were basic sciences (genetics of childhood glaucoma) and surgical management. Conclusion: United States of America, LVPEI, Mandal AK, and “Investigative Ophthalmology” were the top rankers as far as the productivity and publications related to PG are concerned. Articles on molecular genetics in PG have received interest among the ophthalmology community.