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OBJECTIVE To understand the safety of Ilaprazole sodium for injection in clinical practice. METHODS From Jan. 1st 2019 to Feb. 29th 2020， the data of 3 926 valid hospitalized patients receiving Ilaprazole sodium for injection were collected prospectively from 5 third-level hospitals through CHPS， and the post-marketing safety analysis was performed by using retrospective multicenter single cohort study. At the same time， a nested case-control study （the ratio of trial group and control group was 1∶4） was used to confirm the baseline stability of this study cohort and the correlation between adverse reactions and Ilaprazole sodium for injection. RESULTS Among 3 926 patients， 3 patients experienced 5 adverse drug events after using Ilaprazole sodium for injection， with the incidence of 0.076%. There was no serious adverse event， and the occurrence time was 2 days after medication； adverse drug events mainly include elevated liver function indicators （alanine transaminase， aspartate transaminase， total bilirubin）， which were mild and untreated， and all adverse drug events were improved. The results of the nested case-control study showed that the trial group and the control group belonged to the same background baseline， and the occurrence of adverse drug events was more closely related to Ilaprazole sodium for injection. CONCLUSIONS The overall safety of Ilaprazole sodium for injection is relatively high， and the occurrence of adverse events is more related to it.
RESUMEN
OBJECTIVE: To offer guidance for psychiatric patients about rational drug use and improve patient's compliance.METHODS: Clinical pharmacists answered the questions encountered by patients during medication process by means of face-to-face talk with patients or their relatives and telephone inquiry.RESULTS: Patients' drug counseling in psychiatry department covered wide range,much as in the aspects of drug interactions and adverse drug reactions.Due to medication consultation service,patient's consciousness of rational drug use had been improved and some medication errors had been avoided,clinical pharmacists' professional knowledge has been enriched and clinical pharmacy has been enhanced and developed.CONCLUSION: The medication consultation service developed in psychiatric department is of positive practical significance in promoting rational drug use and improving clinical efficacy.