RESUMEN
The goal of periodontal treatment is regeneration of the periodontium. Bone graft and absorbable PLA/PGA membrane have been used for this purpose. In this study, 4x4mm 1-wall intrabony defects were surgically created bilaterally in the mandible of five male beagles. The control group went through a conventional flap operation, while the experimental group I was treated with absorbable PLA/PGA membranes only, group II was treated with absorbable membrane and calcium phosphate. The results are the following : 1. The defect height was 4.82+/-0.45mm in the control group, 4.93+/-0.79mm in the experimental I group, and 4.92+/-0.62mm in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05). 2. The amount of junctional epithelium migration was 30.90+/-9.92% of the defect height in the control group, 39.16+/-7.51% in the experimental I group, and 38.68+/-12.22% in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05). 3. The amount of connective tissue adhesion was 36.38+/-9.03% in the control group, 14.73+/-3.93% in experimental I group, and 27.87+/-9.70% experimental II group. Experimental group I was a statistically significantly different from control group(P<0.05). 4. The amount of new cementum regeneration was 32.92+/-10.51%, 50.04+/-7.61%, and 39.62+/-12.14% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05). 5. The amount of new alveolar bone regeneration was 27.24+/-7.49%, 40.75+/-8.03%, and 36.47+/-15.11% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05). The results suggest that the use of PLA/PGA membrane in 1-wall intrabony defect of beagle dogs may promote periodontal regeneration. Further studies are required to determine their regeneration effects.
Asunto(s)
Animales , Perros , Humanos , Masculino , Regeneración Ósea , Calcio , Tejido Conectivo , Cemento Dental , Inserción Epitelial , Mandíbula , Membranas , Periodoncio , Regeneración , TrasplantesRESUMEN
The most accurate method to assess bone level is the histometric measurement. However it causes discomfort in patients and damage to the regenerated tissues. in the present study, we used 4 type regenerative therapies. The present study evaluated the clinical reliability and accuracy of bone probing measurements and radiographic bone level in the assessment of bone level by comparing those results with histometric confirmed bone level. Twentyfour(24) intrabony defects(4x4mm 1-wall intrabony defects) were surgically created in the mandibular second and fourth premolars of 6 beagle dogs. The control group underwent a conventional flap operation. Experimental group 1 was treated with calcium phosphate glass only, and while experimental group 2 was treated with GTR and experimental group 3 was treated with calcium phosphate glass and GTR. The subjects were sacrificed 8 weeks after the operation and a bone probing measurements, radiographic measurement and histometric measurement was performed. The correlation between bone probing measurements(BP) and histometric measurement(HL), and radiographic measurement(RL) and histometric measurement(HL) were analyzed with Spearman's rank correlation analysis and the statistical significance with respect to the type of regenerative therapies was analyzed with the Kruskal Wallis test. The coefficeint of correlation to HL was 0.73 for RL and 0.90 for BP. The type of regenerative therapies had no significant effect on the difference between HL and other measurements. The results of this study suggests that bone probing measurements most closely represents actual bone level. So bone probing measurements may be a good clinical method for assessing the bone level following any type of periodontal regenerative therapies.